5ZK7

Stapled-peptides tailored against initiation of translation

Summary for 5ZK7

Entry DOI	10.2210/pdb5zk7/pdb
Descriptor	Eukaryotic translation initiation factor 4E, ACE-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-PHE-ARG-NH2, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
Functional Keywords	cap dependent translation, rna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	49687.25
Authors	Lama, D.,Liberator, A.,Frosi, Y.,Nakhle, J.,Tsomia, N.,Bashir, T.,Lane, D.P.,Brown, C.J.,Verma, C.S.,Auvin, S.,Ciesielski, F.,Uhring, M. (deposition date: 2018-03-23, release date: 2019-02-20, Last modification date: 2023-11-22)
Primary citation	Lama, D.,Liberatore, A.M.,Frosi, Y.,Nakhle, J.,Tsomaia, N.,Bashir, T.,Lane, D.P.,Brown, C.J.,Verma, C.S.,Auvin, S. Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10:2489-2500, 2019 Cited by PubMed: 30881679 DOI: 10.1039/c8sc03759k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation