5ZK7

Stapled-peptides tailored against initiation of translation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation
B	0003723	molecular_function	RNA binding
B	0003743	molecular_function	translation initiation factor activity
B	0005737	cellular_component	cytoplasm
B	0006413	biological_process	translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MGT A 1001

Chain	Residue
A	TRP56
A	MET101
A	TRP102
A	GLU103
A	ARG157
A	HOH1112

---

site_id	AC2
Number of Residues	1
Details	binding site for residue IOD A 1002

Chain	Residue
A	GLY88

---

site_id	AC3
Number of Residues	1
Details	binding site for residue IOD A 1003

Chain	Residue
A	ASN77

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 1004

Chain	Residue
A	HOH1139
B	ASN77
A	ASN77

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 1005

Chain	Residue
A	ARG128
A	LEU187
C	ARG12

---

site_id	AC6
Number of Residues	7
Details	binding site for residue MGT B 1001

Chain	Residue
A	PRO87
A	ARG109
B	TRP56
B	MET101
B	TRP102
B	GLU103
B	ARG157

---

site_id	AC7
Number of Residues	8
Details	binding site for Di-peptide ACE C 0 and ARG C 1

Chain	Residue
A	PRO38
B	PRO38
B	GLN40
B	HOH1107
C	TYR2
C	HOH202
C	HOH205
D	ARG1

---

site_id	AC8
Number of Residues	11
Details	binding site for Di-peptide ARG C 4 and MK8 C 5

Chain	Residue
B	GLU132
B	ARG186
C	SER3
C	GLN6
C	LEU7
C	LEU8
C	MK89
C	HOH204
D	MK89
D	PHE11
D	ARG12

---

site_id	AC9
Number of Residues	10
Details	binding site for Di-peptide MK8 C 5 and GLN C 6

Chain	Residue
A	ILE35
C	TYR2
C	SER3
C	ARG4
C	LEU7
C	LEU8
C	MK89
C	LEU10
C	HOH206
D	MK89

---

site_id	AD1
Number of Residues	12
Details	binding site for residues MK8 C 5 and MK8 C 9

Chain	Residue
A	HIS33
A	ILE35
C	SER3
C	ARG4
C	GLN6
C	LEU7
C	LEU8
C	LEU10
C	PHE11
D	ARG4
D	MK85
D	MK89

---

site_id	AD2
Number of Residues	11
Details	binding site for Di-peptide LEU C 8 and MK8 C 9

Chain	Residue
A	HIS33
A	ILE35
C	ARG4
C	MK85
C	GLN6
C	LEU7
C	LEU10
C	PHE11
D	ARG4
D	MK85
D	LEU8

---

site_id	AD3
Number of Residues	13
Details	binding site for Di-peptide MK8 C 9 and LEU C 10

Chain	Residue
A	HIS33
A	ILE35
B	HIS37
B	VAL69
B	GLU70
C	MK85
C	GLN6
C	LEU7
C	LEU8
C	PHE11
C	ARG12
D	ARG4
D	MK85

---

site_id	AD4
Number of Residues	8
Details	binding site for Di-peptide ARG C 12 and NH2 C 13

Chain	Residue
A	ALA29
A	ARG128
A	GLU132
A	ARG186
A	CL1005
C	LEU10
C	PHE11
D	ARG4

---

site_id	AD5
Number of Residues	10
Details	binding site for Di-peptide ACE D 0 and ARG D 1

Chain	Residue
B	GLN40
B	HOH1111
C	ACE0
D	TYR2
D	HOH206
A	PRO38
A	LEU39
A	GLN40
A	HOH1105
B	PRO38

---

site_id	AD6
Number of Residues	13
Details	binding site for Di-peptide ARG D 4 and MK8 D 5

Chain	Residue
A	GLU132
A	ARG186
B	GLU32
C	MK89
C	PHE11
C	ARG12
D	SER3
D	GLN6
D	LEU7
D	LEU8
D	MK89
D	HOH203
D	HOH205

---

site_id	AD7
Number of Residues	13
Details	binding site for residues MK8 D 5 and MK8 D 9

Chain	Residue
B	GLU32
B	ILE35
C	ARG4
C	MK85
C	MK89
D	SER3
D	ARG4
D	GLN6
D	LEU7
D	LEU8
D	LEU10
D	PHE11
D	HOH205

---

site_id	AD8
Number of Residues	10
Details	binding site for Di-peptide MK8 D 5 and GLN D 6

Chain	Residue
B	GLU32
C	MK89
D	TYR2
D	SER3
D	ARG4
D	LEU7
D	LEU8
D	MK89
D	LEU10
D	HOH205

---

site_id	AD9
Number of Residues	12
Details	binding site for Di-peptide LEU D 8 and MK8 D 9

Chain	Residue
A	LEU135
B	GLU32
B	ILE35
C	ARG4
C	MK85
C	LEU8
D	ARG4
D	MK85
D	GLN6
D	LEU7
D	LEU10
D	PHE11

---

site_id	AE1
Number of Residues	13
Details	binding site for Di-peptide MK8 D 9 and LEU D 10

Chain	Residue
A	HIS37
A	VAL69
B	GLU32
B	ILE35
C	ARG4
C	MK85
D	MK85
D	GLN6
D	LEU7
D	LEU8
D	PHE11
D	ARG12
D	HOH202

---

site_id	AE2
Number of Residues	7
Details	binding site for Di-peptide ARG D 12 and NH2 D 13

Chain	Residue
A	TYR34
B	ARG128
B	GLU132
C	ARG4
D	LEU10
D	PHE11
D	HOH204

---

Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW

Chain	Residue	Details
A	ASP90-TRP113

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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