5ZK7
Stapled-peptides tailored against initiation of translation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Eukaryotic translation initiation factor 4E | polymer | 191 | 22290.3 | 2 | UniProt (P06730) Pfam (PF01652) | Homo sapiens (Human) | eIF4E |
| 2 | C, D (C, D) | ACE-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-PHE-ARG-NH2 | polymer | 14 | 1633.0 | 2 | Homo sapiens | ||
| 3 | E, J (A, B) | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 539.2 | 2 | Chemie (MGT) | |||
| 4 | F, G, K, L, M (A, C, D) | IODIDE ION | non-polymer | 126.9 | 5 | Chemie (IOD) | |||
| 5 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 217 (UniProt: P06730)
| PDB | External Database | Details |
|---|---|---|
| Met 27 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47846.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1840.5 | |
| All* | Total formula weight | 49687.3 |
