5ZK5
Stapled-peptides tailored against initiation of translation
Summary for 5ZK5
Entry DOI | 10.2210/pdb5zk5/pdb |
Descriptor | Eukaryotic translation initiation factor 4E, LYS-ARG-TYR-SER-ARG-GLU-GLN-LEU-LEU-MK8-PHE-GLN-ARG-MK8, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | cap dependent translation, rna binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 24865.04 |
Authors | Lama, D.,Liberator, A.,Frosi, Y.,Nakhle, J.,Tsomia, N.,Bashir, T.,Lane, D.P.,Brown, C.J.,Verma, C.S.,Auvin, S.,Ciesielski, F.,Uhring, M. (deposition date: 2018-03-23, release date: 2019-02-20, Last modification date: 2023-11-22) |
Primary citation | Lama, D.,Liberatore, A.M.,Frosi, Y.,Nakhle, J.,Tsomaia, N.,Bashir, T.,Lane, D.P.,Brown, C.J.,Verma, C.S.,Auvin, S. Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10:2489-2500, 2019 Cited by PubMed: 30881679DOI: 10.1039/c8sc03759k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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