5ZK5
Stapled-peptides tailored against initiation of translation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Eukaryotic translation initiation factor 4E | polymer | 191 | 22290.3 | 1 | UniProt (P06730) Pfam (PF01652) | Homo sapiens (human) | eIF4E,eIF-4F 25 kDa subunit |
| 2 | B (B) | LYS-ARG-TYR-SER-ARG-GLU-GLN-LEU-LEU-MK8-PHE-GLN-ARG-MK8 | polymer | 17 | 2035.5 | 1 | UniProt (Q04637) | Homo sapiens | |
| 3 | C (A) | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (MGT) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 28 - 217 (UniProt: P06730)
B: 2 - 101 (UniProt: Q04637)
| PDB | External Database | Details |
|---|---|---|
| Met 27 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| Ser 6 | Asp 613 | conflict |
| Gln 9 | Phe 616 | conflict |
| Mk8 12 | Gly 619 | conflict |
| Arg 15 | Phe 622 | conflict |
| Mk8 101 | Ile 623 | conflict |
| Nh2 17 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24325.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 539.2 | |
| All* | Total formula weight | 24865.0 |
