7ZOC
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5JBB
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5JBC
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8AE4
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![BU of 8ae4 by Molmil](/molmil-images/mine/8ae4) | Crystal structure of human legumain in complex with Clitocypin 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Clitocypin-2, ... | Authors: | Elamin, T, Brandstetter, H, Dall, E. | Deposit date: | 2022-07-12 | Release date: | 2022-09-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction. J.Biol.Chem., 298, 2022
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8AE5
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![BU of 8ae5 by Molmil](/molmil-images/mine/8ae5) | Crystal structure of human legumain in complex with macrocypin 1a | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Legumain, ... | Authors: | Elamin, T, Brandstetter, H, Dall, E. | Deposit date: | 2022-07-12 | Release date: | 2022-09-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction. J.Biol.Chem., 298, 2022
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5JB9
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![BU of 5jb9 by Molmil](/molmil-images/mine/5jb9) | Crystal structure of factor IXa K98T variant in complex with PPACK | Descriptor: | CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... | Authors: | Kristensen, L.H, Brandstetter, H. | Deposit date: | 2016-04-13 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem.J., 473, 2016
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5JBA
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8B4V
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![BU of 8b4v by Molmil](/molmil-images/mine/8b4v) | X-ray structure of furin (PCSK3) in complex with benzamidine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, CALCIUM ION, ... | Authors: | Dahms, S.O, Brandstetter, H. | Deposit date: | 2022-09-21 | Release date: | 2023-10-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19, 2024
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8B4W
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![BU of 8b4w by Molmil](/molmil-images/mine/8b4w) | X-ray structure of furin (PCSK3) in complex with 1H-isoindol-3-amine | Descriptor: | 1H-isoindol-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Dahms, S.O, Brandstetter, H. | Deposit date: | 2022-09-21 | Release date: | 2023-10-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19, 2024
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8B4X
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![BU of 8b4x by Molmil](/molmil-images/mine/8b4x) | X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-R-Tle-K-6-(aminomethyl)-3-amino-isoindol | Descriptor: | CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Dahms, S.O, Brandstetter, H. | Deposit date: | 2022-09-21 | Release date: | 2023-10-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19, 2024
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5JB8
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2WPM
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![BU of 2wpm by Molmil](/molmil-images/mine/2wpm) | factor IXa superactive mutant, EGR-CMK inhibited | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | Authors: | Zogg, T, Brandstetter, H. | Deposit date: | 2009-08-06 | Release date: | 2009-12-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009
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2WPI
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![BU of 2wpi by Molmil](/molmil-images/mine/2wpi) | factor IXa superactive double mutant | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | Authors: | Zogg, T, Brandstetter, H. | Deposit date: | 2009-08-06 | Release date: | 2009-12-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009
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2WPL
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![BU of 2wpl by Molmil](/molmil-images/mine/2wpl) | factor IXa superactive triple mutant, EDTA-soaked | Descriptor: | COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, D-PHE-PRO-ARG-CHLOROMETHYL KETONE | Authors: | Zogg, T, Brandstetter, H. | Deposit date: | 2009-08-06 | Release date: | 2009-12-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009
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2WPJ
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![BU of 2wpj by Molmil](/molmil-images/mine/2wpj) | factor IXa superactive triple mutant, NaCl-soaked | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | Authors: | Zogg, T, Brandstetter, H. | Deposit date: | 2009-08-06 | Release date: | 2009-12-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009
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2WPH
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![BU of 2wph by Molmil](/molmil-images/mine/2wph) | factor IXa superactive triple mutant | Descriptor: | CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ... | Authors: | Zogg, T, Brandstetter, H. | Deposit date: | 2009-08-06 | Release date: | 2009-12-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009
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2WPK
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![BU of 2wpk by Molmil](/molmil-images/mine/2wpk) | factor IXa superactive triple mutant, ethylene glycol-soaked | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, ... | Authors: | Zogg, T, Brandstetter, H. | Deposit date: | 2009-08-06 | Release date: | 2009-12-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17, 2009
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2Y50
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2Y3U
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5MS4
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![BU of 5ms4 by Molmil](/molmil-images/mine/5ms4) | Kallikrein-related peptidase 8 leupeptin inhibitor complex | Descriptor: | CALCIUM ION, Kallikrein-8, LEUPEPTIN, ... | Authors: | Debela, M, Magdolen, V, Skala, W, Bode, W, Brandstetter, H, Goettig, P. | Deposit date: | 2016-12-30 | Release date: | 2018-01-17 | Last modified: | 2019-10-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Sci Rep, 8, 2018
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5NIJ
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5MS3
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![BU of 5ms3 by Molmil](/molmil-images/mine/5ms3) | Kallikrein-related peptidase 8 calcium complex | Descriptor: | CALCIUM ION, Kallikrein-8 | Authors: | Debela, M, Magdolen, V, Skala, W, Bode, W, Brandstetter, H, Goettig, P. | Deposit date: | 2016-12-30 | Release date: | 2018-01-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Specificity profiles and antagonistic Ca2+ and Zn2+ regulation of human KLK8/neuropsin activity by modules identified in crystal structures To Be Published
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5LPE
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![BU of 5lpe by Molmil](/molmil-images/mine/5lpe) | Kallikrein-related peptidase 10 complex with Zn2+ | Descriptor: | Kallikrein-10, SULFATE ION, ZINC ION | Authors: | Goettig, P, Debela, M, Magdolen, V, Bode, W, Brandstetter, H. | Deposit date: | 2016-08-12 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10. Biol.Chem., 397, 2016
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5LPF
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![BU of 5lpf by Molmil](/molmil-images/mine/5lpf) | Kallikrein-related peptidase 10 | Descriptor: | Kallikrein-10, SULFATE ION | Authors: | Goettig, P, Debela, M, Magdolen, V, Bode, W, Brandstetter, H. | Deposit date: | 2016-08-12 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10. Biol.Chem., 397, 2016
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1S0P
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![BU of 1s0p by Molmil](/molmil-images/mine/1s0p) | Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum. | Descriptor: | Adenylyl cyclase-associated protein, MAGNESIUM ION | Authors: | Ksiazek, D, Brandstetter, H, Israel, L, Bourenkov, G.P, Katchalova, G, Janssen, K.P, Bartunik, H.D, Noegel, A.A, Schleicher, M, Holak, T.A. | Deposit date: | 2004-01-01 | Release date: | 2004-01-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | STRUCTURE OF THE N-TERMINAL DOMAIN OF THE ADENYLYL
CYCLASE-ASSOCIATED PROTEIN (CAP) FROM DICTYOSTELIUM DISCOIDEUM Structure, 11, 2003
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