2WPM

factor IXa superactive mutant, EGR-CMK inhibited

Summary for 2WPM

Entry DOI	10.2210/pdb2wpm/pdb
Related	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL
Descriptor	COAGULATION FACTOR IXA LIGHT CHAIN, GLU-GLY-ARG-CHLOROMETHYL KETONE, COAGULATION FACTOR IXA HEAVY CHAIN, ... (5 entities in total)
Functional Keywords	serine protease, zymogen, hydrolase, glycoprotein, hydroxylation, phosphoprotein, sulfation, hemostasis, hemophilia, xase-like variant, communication channel, gamma-carboxyglutamic acid, egf-like domain, disease mutation, blood clotting
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted : P00740 P00740
Total number of polymer chains	3
Total formula weight	32966.52
Authors	Zogg, T.,Brandstetter, H. (deposition date: 2009-08-06, release date: 2009-12-22, Last modification date: 2023-12-20)
Primary citation	Zogg, T.,Brandstetter, H. Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa Structure, 17:1669-, 2009 Cited by PubMed: 20004170 DOI: 10.1016/J.STR.2009.10.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation