5JBB

Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with EGR-chloromethylketone

Summary for 5JBB

• Entry DOI: 10.2210/pdb5jbb/pdb
• Related PRD ID: PRD_000288
• Descriptor: Coagulation factor IX, CALCIUM ION, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ... (6 entities in total)
• Functional Keywords: blood clotting, hydrolase, glycoprotein, haemostasis
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : P00740 P00740
• Total number of polymer chains: 2
• Total formula weight: 33010.04

Authors

Kristensen, L.H.,Brandstetter, H. (deposition date: 2016-04-13, release date: 2016-06-01, Last modification date: 2024-01-10)

• Primary citation: Kristensen, L.H.,Olsen, O.H.,Blouse, G.E.,Brandstetter, H.; Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.; Biochem.J., 473:2395-2411, 2016; PubMed: 27208168; DOI: 10.1042/BCJ20160336

Experimental method

X-RAY DIFFRACTION (1.56 Å)