5JBB
Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with EGR-chloromethylketone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Coagulation factor IX | polymer | 58 | 6395.3 | 1 | UniProt (P00740) Pfam (PF14670) | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 2 | B (S) | Coagulation factor IX | polymer | 235 | 26100.7 | 1 | UniProt (P00740) Pfam (PF00089) | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 3 | C (S) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | D (S) | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide | non-polymer | 395.9 | 1 | BIRD (PRD_000288) Chemie (0GJ) | |||
| 5 | E (S) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | F, G (E, S) | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
S: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Ile 16 | Val 227 | engineered mutation |
| Thr 98 | Lys 311 | engineered mutation |
| Thr 177 | Tyr 391 | engineered mutation |
| Val 213 | Ile 429 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32496.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 514.1 | |
| All* | Total formula weight | 33010.0 |
