2W97
| Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide | 分子名称: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, GLYCEROL, ... | 著者 | Brown, C.J, Verma, C.S, Walkinshaw, M.D, Lane, D.P. | 登録日 | 2009-01-22 | 公開日 | 2010-03-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site. Cell Cycle, 8, 2009
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1UZ9
| Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins. | 分子名称: | (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, CHLORIDE ION, INSULIN, ... | 著者 | Whittingham, J.L, Jonassen, I, Havelund, S, Roberts, S.M, Dodson, E.J, Verma, C.S, Wilkinson, A.J, Dodson, G.G. | 登録日 | 2004-03-08 | 公開日 | 2005-03-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins Biochemistry, 43, 2004
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3PVA
| PENICILLIN V ACYLASE FROM B. SPHAERICUS | 分子名称: | PROTEIN (PENICILLIN V ACYLASE) | 著者 | Suresh, C.G, Pundle, A.V, Rao, K.N, Sivaraman, H, Brannigan, J.A, Mcvey, C.E, Verma, C.S, Dauter, Z, Dodson, E.J, Dodson, G.G. | 登録日 | 1998-11-13 | 公開日 | 1999-11-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members. Nat.Struct.Biol., 6, 1999
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4BEA
| Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative | 分子名称: | Eukaryotic translation initiation factor 4E, STAPLED EIF4E INTERACTING PEPTIDE | 著者 | Quah, S.T, Lama, D, Verma, C.S, Lane, D.P, Brown, C.J. | 登録日 | 2013-03-07 | 公開日 | 2013-12-11 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Rational Optimization of Conformational Effects Induced by Hydrocarbon Staples in Peptides and Their Binding Interfaces. Sci.Rep., 3, 2013
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4AZA
| Improved eIF4E binding peptides by phage display guided design. | 分子名称: | EIF4G1_D5S PEPTIDE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | 著者 | Chew, W.Z, Quah, S.T, Verma, C.S, Liu, Y, Lane, D.P, Brown, C.J. | 登録日 | 2012-06-25 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Improved Eif4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects. Plos One, 7, 2012
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2J5I
| Crystal Structure of Hydroxycinnamoyl-CoA Hydratase-Lyase | 分子名称: | P-HYDROXYCINNAMOYL COA HYDRATASE/LYASE | 著者 | Leonard, P.M, Brzozowski, A.M, Lebedev, A, Marshall, C.M, Smith, D.J, Verma, C.S, Walton, N.J, Grogan, G. | 登録日 | 2006-09-18 | 公開日 | 2006-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The 1.8 A Resolution Structure of Hydroxycinnamoyl- Coenzyme a Hydratase-Lyase (Hchl) from Pseudomonas Fluorescens, an Enzyme that Catalyses the Transformation of Feruloyl-Coenzyme a to Vanillin. Acta Crystallogr.,Sect.D, 62, 2006
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2PVA
| OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS | 分子名称: | DITHIANE DIOL, PENICILLIN V ACYLASE | 著者 | Suresh, C.G, Pundle, A.V, Rao, K.N, SivaRaman, H, Brannigan, J.A, McVey, C.E, Verma, C.S, Dauter, Z, Dodson, E.J, Dodson, G.G. | 登録日 | 1998-11-13 | 公開日 | 2000-07-26 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members. Nat.Struct.Biol., 6, 1999
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1O8U
| The 2 Angstrom Structure of 6-Oxo Camphor Hydrolase: New Structural Diversity in the Crotonase Superfamily | 分子名称: | 6-OXO CAMPHOR HYDROLASE, SODIUM ION | 著者 | Grogan, G, Whittingham, J.L, Turkenburg, J.P, Verma, C.S, Walsh, M.A. | 登録日 | 2002-12-04 | 公開日 | 2003-01-24 | 最終更新日 | 2019-01-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The 2 a Crystal Structure of 6-Oxo Camphor Hydrolase: New Structural Diversity in the Crotonase Superfamily J.Biol.Chem., 278, 2003
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1QIZ
| HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL | 分子名称: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | 著者 | Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. | 登録日 | 1999-06-18 | 公開日 | 1999-06-22 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999
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1QJ0
| HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR | 分子名称: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | 著者 | Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. | 登録日 | 1999-06-18 | 公開日 | 1999-06-22 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999
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1QIY
| HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL | 分子名称: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | 著者 | Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. | 登録日 | 1999-06-18 | 公開日 | 1999-06-22 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999
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1SML
| METALLO BETA LACTAMASE L1 FROM STENOTROPHOMONAS MALTOPHILIA | 分子名称: | PROTEIN (PENICILLINASE), ZINC ION | 著者 | Ullah, J.H, Walsh, T.R, Taylor, I.A, Emery, D.C, Verma, C.S, Gamblin, S.J, Spencer, J. | 登録日 | 1998-09-22 | 公開日 | 1999-09-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution. J.Mol.Biol., 284, 1998
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1E3A
| A slow processing precursor penicillin acylase from Escherichia coli | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hewitt, L, Kasche, V, Lummer, K, Lewis, R.J, Murshudov, G.N, Verma, C.S, Dodson, G.G, Wilson, K.S. | 登録日 | 2000-06-07 | 公開日 | 2000-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of a Slow Processing Precursor Penicillin Acylase from Escherichia Coli Reveals the Linker Peptide Blocking the Active-Site Cleft J.Mol.Biol., 302, 2000
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1FSE
| CRYSTAL STRUCTURE OF THE BACILLUS SUBTILIS REGULATORY PROTEIN GERE | 分子名称: | GERE, GLYCEROL, SULFATE ION | 著者 | Ducros, V.M.-A, Lewis, R.J, Verma, C.S, Dodson, E.J, Leonard, G, Turkenburg, J.P, Murshudov, G.N, Wilkinson, A.J, Brannigan, J.A. | 登録日 | 2000-09-08 | 公開日 | 2001-03-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis. J.Mol.Biol., 306, 2001
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1HG7
| High resolution structure of HPLC-12 type III antifreeze protein from Ocean Pout Macrozoarces americanus | 分子名称: | HPLC-12 TYPE III ANTIFREEZE PROTEIN, SULFATE ION | 著者 | Antson, A.A, Smith, D.J, Roper, D.I, Lewis, S, Caves, L.S.D, Verma, C.S, Buckley, S.L, Lillford, P.J, Hubbard, R.E. | 登録日 | 2000-12-13 | 公開日 | 2001-01-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Understanding the Mechanism of Ice Binding by Type III Antifreeze Protein J.Mol.Biol., 305, 2001
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5ZK9
| Stapled-peptides tailored against initiation of translation | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ACE-ARG-ILE-ILE-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-LYS-NH2, DI(HYDROXYETHYL)ETHER, ... | 著者 | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M. | 登録日 | 2018-03-23 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019
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5ZK7
| Stapled-peptides tailored against initiation of translation | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ACE-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-PHE-ARG-NH2, CHLORIDE ION, ... | 著者 | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M. | 登録日 | 2018-03-23 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019
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5ZML
| Stapled-peptides tailored against initiation of translation | 分子名称: | 1,2-ETHANEDIOL, ACE-LYS-LYS-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-PHE-ARG-ARG, Eukaryotic translation initiation factor 4E, ... | 著者 | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Yano, J. | 登録日 | 2018-04-04 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019
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5ZJY
| Stapled-peptides tailored against initiation of translation | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, LYS-LYS-ARG-TYR-SER-ARG-2JN-GLN-LEU-LEU-2JN-PHE | 著者 | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, B, Uhring, M. | 登録日 | 2018-03-22 | 公開日 | 2019-03-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019
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5ZK5
| Stapled-peptides tailored against initiation of translation | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, LYS-ARG-TYR-SER-ARG-GLU-GLN-LEU-LEU-MK8-PHE-GLN-ARG-MK8 | 著者 | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M. | 登録日 | 2018-03-23 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019
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5ZJZ
| Stapled-peptides tailored against initiation of translation | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E | 著者 | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M. | 登録日 | 2018-03-22 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019
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7ROV
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4UE1
| Structure of the stapled peptide YS-01 bound to MDM2 | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE MDM2, YS-01 | 著者 | Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C. | 登録日 | 2014-12-14 | 公開日 | 2016-01-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design. J Phys Chem Lett, 7, 2016
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4UD7
| Structure of the stapled peptide YS-02 bound to MDM2 | 分子名称: | MDM2, YS-02 | 著者 | Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C. | 登録日 | 2014-12-08 | 公開日 | 2016-01-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design. J Phys Chem Lett, 7, 2016
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6Q38
| The Crystal structure of CK2a bound to P1-C4 | 分子名称: | 3,5-bis(1-methyl-1,2,3-triazol-4-yl)benzoic acid, BENZOIC ACID, Casein kinase II subunit alpha, ... | 著者 | Brear, P, Iegre, J, Baker, D, Tan, Y, Sore, H, Donovan, D, Spring, D, Chandra, V, Hyvonen, M. | 登録日 | 2018-12-03 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction. Chem Sci, 10, 2019
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