1QJ0

HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR

Summary for 1QJ0

Related1QIZ 1QIY
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, ZINC ION, ... (5 entities in total)
Functional Keywordshormone, glucose metabolism, diabetes, insulin mutant
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight11851.63
Authors
Tang, L.,Whittingham, J.L.,Verma, C.S.,Caves, L.S.D.,Dodson, G.G. (deposition date: 1999-06-18, release date: 1999-06-22, Last modification date: 2017-07-05)
Primary citation
Tang, L.,Whittingham, J.L.,Verma, C.S.,Caves, L.S.D.,Dodson, G.G.
Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38:12041-, 1999
PubMed: 10508408 (PDB entries with the same primary citation)
DOI: 10.1021/BI990700K
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1507.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution