7ROV

KRAS G12D Mutant in complex with GMPPCP and cyclic peptide MP-9903

Summary for 7ROV

• Entry DOI: 10.2210/pdb7rov/pdb
• Related PRD ID: PRD_002482
• Descriptor: Isoform 2B of GTPase KRas, Cyclic peptide MP-9903, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: kras, cyclic peptide, non-natural amino acid, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 47532.29

Authors

Orth, P. (deposition date: 2021-08-02, release date: 2021-09-22, Last modification date: 2023-11-15)

• Primary citation: Lim, S.,Boyer, N.,Boo, N.,Huang, C.,Venkatachalam, G.,Angela Juang, Y.C.,Garrigou, M.,Kaan, H.Y.K.,Duggal, R.,Peh, K.M.,Sadruddin, A.,Gopal, P.,Yuen, T.Y.,Ng, S.,Kannan, S.,Brown, C.J.,Verma, C.S.,Orth, P.,Peier, A.,Ge, L.,Yu, X.,Bhatt, B.,Chen, F.,Wang, E.,Li, N.J.,Gonzales, R.J.,Stoeck, A.,Henry, B.,Sawyer, T.K.,Lane, D.P.,Johannes, C.W.,Biswas, K.,Partridge, A.W.; Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.; Chem Sci, 12:15975-15987, 2021; PubMed: 35024121; DOI: 10.1039/d1sc05187c

Experimental method

X-RAY DIFFRACTION (1.32 Å)