7ROV
KRAS G12D Mutant in complex with GMPPCP and cyclic peptide MP-9903
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 2B of GTPase KRas | polymer | 189 | 21588.7 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, D (E, F) | Cyclic peptide MP-9903 | polymer | 14 | 1585.9 | 2 | BIRD (PRD_002482) | synthetic construct | |
| 3 | E, G (A, B) | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | non-polymer | 521.2 | 2 | Chemie (GCP) | |||
| 4 | F, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | H (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | J, K, L, M (A, B, E, F) | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 188 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 46349.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1183.1 | |
| All* | Total formula weight | 47532.3 |
