6JC3
| The Cryo-EM structure of nucleoprotein-RNA complex of Newcastle disease virus | Descriptor: | Nucleocapsid, polyU | Authors: | Song, X, Shan, H, Zhu, Y, Ding, W, Ouyang, S, Shen, Q.T, Liu, Z.J. | Deposit date: | 2019-01-28 | Release date: | 2019-08-07 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome. Elife, 8, 2019
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6M7D
| Structure of ncleoprotein of sendai virus | Descriptor: | Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') | Authors: | Shen, Q, Shan, H, Zhang, N. | Deposit date: | 2020-03-18 | Release date: | 2021-03-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | structure of the nucleocapsid of sendai virus at 2.9 Angstroms resolution To Be Published
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8JR9
| Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ... | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, He, X, Shan, H, Li, J, Wang, K, Li, Y, Hu, W, Wu, K, Shen, J, Xu, H.E. | Deposit date: | 2023-06-16 | Release date: | 2023-08-02 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Conserved class B GPCR activation by a biased intracellular agonist. Nature, 621, 2023
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7EWQ
| Structure of Mumps virus nucleocapsid ring | Descriptor: | Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') | Authors: | Su, X, Shen, Q, Shan, H. | Deposit date: | 2021-05-25 | Release date: | 2021-06-23 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural plasticity of mumps virus nucleocapsids
for genome protection and condensation To Be Published
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5FIR
| Crystal structure of C. elegans XRN2 in complex with the XRN2-binding domain of PAXT-1 | Descriptor: | 5'-3' EXORIBONUCLEASE 2 HOMOLOG, PAXT-1, SULFATE ION | Authors: | Richter, H, Katic, I, Gut, H, Grosshans, H. | Deposit date: | 2015-10-02 | Release date: | 2016-01-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.836 Å) | Cite: | Structural Basis and Function of Xrn2-Binding by Xtb Domains Nat.Struct.Mol.Biol., 23, 2016
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6FQ3
| Crystal structure of Danio rerio Lin41 filamin-NHL domains in complex with lin-29A 5'UTR 13mer RNA | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase TRIM71, RNA (5'-R(*GP*GP*AP*GP*UP*CP*CP*AP*AP*CP*UP*CP*C)-3') | Authors: | Kumari, P, Aeschimann, F, Gaidatzis, D, Keusch, J.J, Ghosh, P, Neagu, A, Pachulska-Wieczorek, K, Bujnicki, J.M, Gut, H, Grosshans, H, Ciosk, R. | Deposit date: | 2018-02-13 | Release date: | 2018-05-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Nat Commun, 9, 2018
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6FPT
| Crystal structure of Danio rerio Lin41 filamin-NHL domains | Descriptor: | E3 ubiquitin-protein ligase TRIM71 | Authors: | Kumari, P, Aeschimann, F, Gaidatzis, D, Keusch, J.J, Ghosh, P, Neagu, A, Pachulska-Wieczorek, K, Bujnicki, J.M, Gut, H, Grosshans, H, Ciosk, R. | Deposit date: | 2018-02-12 | Release date: | 2018-05-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Nat Commun, 9, 2018
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6FQL
| Crystal structure of Danio rerio Lin41 filamin-NHL domains in complex with mab-10 3'UTR 13mer RNA | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase TRIM71, RNA (5'-R(*UP*GP*CP*AP*UP*UP*UP*AP*AP*UP*GP*CP*A)-3') | Authors: | Kumari, P, Aeschimann, F, Gaidatzis, D, Keusch, J.J, Ghosh, P, Neagu, A, Pachulska-Wieczorek, K, Bujnicki, J.M, Gut, H, Grosshans, H, Ciosk, R. | Deposit date: | 2018-02-14 | Release date: | 2018-05-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.349 Å) | Cite: | Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Nat Commun, 9, 2018
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6ZZR
| The Crystal Structure of human LDHA from Biortus. | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, L-lactate dehydrogenase A chain | Authors: | Wang, F, Lin, D, Cheng, W, Bao, X, Zhu, B, Shang, H. | Deposit date: | 2020-08-05 | Release date: | 2020-08-19 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Crystal Structure of human LDHA from Biortus To Be Published
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7ESF
| The Crystal Structure of human MTH1 from Biortus | Descriptor: | 7,8-dihydro-8-oxoguanine triphosphatase, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL | Authors: | Wang, F, Cheng, W, Shang, H, Wang, R, Zhang, B, Tian, F. | Deposit date: | 2021-05-10 | Release date: | 2021-05-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The Crystal Structure of human MTH1 from Biortus To Be Published
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7CMR
| The Crystal Structure of human MYST1 from Biortus. | Descriptor: | GLYCEROL, Histone acetyltransferase KAT8, ZINC ION | Authors: | Wang, F, Lin, D, Lv, Z, Xu, X, Tan, J, Shang, H. | Deposit date: | 2020-07-28 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Crystal Structure of human MYST1 from Biortus. To Be Published
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7CM2
| The Crystal Structure of human USP7 USP domain from Biortus | Descriptor: | GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Wang, F, Cheng, W, Lv, Z, Lin, D, Zhu, B, Miao, Q, Bao, X, Shang, H. | Deposit date: | 2020-07-24 | Release date: | 2020-08-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The Crystal Structure of human USP7 USP domain from Biortus. To Be Published
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7CML
| The Crystal Structure of human JNK2 from Biortus. | Descriptor: | Mitogen-activated protein kinase 9 | Authors: | Wang, F, Lin, D, Cheng, W, Miao, Q, Huang, Y, Shang, H. | Deposit date: | 2020-07-28 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The Crystal Structure of human JNK2 from Biortus. To Be Published
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4RS6
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7E35
| Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant bound to compound S43 | Descriptor: | N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Non-structural protein 3, ZINC ION | Authors: | Liu, J, Wang, Y, Xu, X, Pan, L. | Deposit date: | 2021-02-08 | Release date: | 2021-03-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol, 28, 2021
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7D6H
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7XF2
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7X1G
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7X1J
| Cryo-EM structure of human BTR1 in the outward-facing state in the presence of NH4Cl. | Descriptor: | Isoform 1 of Solute carrier family 4 member 11, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | Authors: | Yin, Y, Lu, Y, Zuo, P. | Deposit date: | 2022-02-24 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP 2. Nat Commun, 14, 2023
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7X1H
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7X1I
| Cryo-EM structure of human BTR1 in the outward-facing state. | Descriptor: | Isoform 1 of Solute carrier family 4 member 11, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | Authors: | Yin, Y, Lu, Y, Zuo, P. | Deposit date: | 2022-02-24 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP 2. Nat Commun, 14, 2023
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7CR5
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6M3M
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6P9F
| Crystal structure of RAR-related orphan receptor C (NHIS-RORGT(244-487)-L6-SRC1(678-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor | Descriptor: | Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 chimera, trans-4-{(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl}cyclohexane-1-carboxylic acid | Authors: | Sack, J. | Deposit date: | 2019-06-10 | Release date: | 2019-07-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists. Bioorg.Med.Chem.Lett., 29, 2019
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8CRC
| Structure of human Plk1 PBD in complex with Allopole-A | Descriptor: | 7-chloro-4-(cyclopropylmethyl)-1-thioxo-2,4-dihydrothieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one, GLYCEROL, Serine/threonine-protein kinase PLK1 | Authors: | Kirsch, K, Park, J.E, Lee, K.S. | Deposit date: | 2023-03-08 | Release date: | 2023-08-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition. Proc.Natl.Acad.Sci.USA, 120, 2023
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