7CR5

Complex structure of a human monoclonal antibody with SARS-CoV-2 nucleocapsid protein NTD

Summary for 7CR5

Entry DOI	10.2210/pdb7cr5/pdb
Descriptor	Nucleoprotein, monoclonal antibody chain H, monoclonal antibody chain L, ... (5 entities in total)
Functional Keywords	human monoclonal antibody, sars-cov-2, nucleocapsid protein, complex, viral protein, viral protein-immune system complex, viral protein/immune system
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More
Total number of polymer chains	3
Total formula weight	62038.24
Authors	Chen, S.,Kang, S. (deposition date: 2020-08-12, release date: 2021-03-24, Last modification date: 2023-11-29)
Primary citation	Kang, S.,Yang, M.,He, S.,Wang, Y.,Chen, X.,Chen, Y.Q.,Hong, Z.,Liu, J.,Jiang, G.,Chen, Q.,Zhou, Z.,Zhou, Z.,Huang, Z.,Huang, X.,He, H.,Zheng, W.,Liao, H.X.,Xiao, F.,Shan, H.,Chen, S. A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation. Nat Commun, 12:2697-2697, 2021 Cited by PubMed: 33976229 DOI: 10.1038/s41467-021-23036-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation