8WST

Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH

Summary for 8WST

• Entry DOI: 10.2210/pdb8wst/pdb
• EMDB information: 37824
• Descriptor: Guanine nucleotide-binding protein G(q) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: melanin-concentrating hormone receptors2, gpcr, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 128821.24

Authors

Zhao, L.,He, Q.,Yuan, Q.,Gu, Y.,Shan, H.,Hu, W.,Wu, K.,Xu, H.E.,Zhang, Y.,Wu, C. (deposition date: 2023-10-17, release date: 2024-06-19, Last modification date: 2024-06-26)

• Primary citation: He, Q.,Yuan, Q.,Shan, H.,Wu, C.,Gu, Y.,Wu, K.,Hu, W.,Zhang, Y.,He, X.,Xu, H.E.,Zhao, L.H.; Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.; Cell Discov, 10:48-48, 2024; PubMed: 38710677; DOI: 10.1038/s41421-024-00679-8

Experimental method

ELECTRON MICROSCOPY (2.4 Å)