5WJ9
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![BU of 5wj9 by Molmil](/molmil-images/mine/5wj9) | Human TRPML1 channel structure in agonist-bound open conformation | Descriptor: | 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1 | Authors: | Schmiege, P, Li, X. | Deposit date: | 2017-07-21 | Release date: | 2017-10-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Human TRPML1 channel structures in open and closed conformations. Nature, 550, 2017
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7MGL
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![BU of 7mgl by Molmil](/molmil-images/mine/7mgl) | Structure of human TRPML1 with ML-SI3 | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Mucolipin-1, N-{(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide | Authors: | Schmiege, P, Li, X. | Deposit date: | 2021-04-12 | Release date: | 2021-06-16 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Atomic insights into ML-SI3 mediated human TRPML1 inhibition. Structure, 29, 2021
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5WJ5
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![BU of 5wj5 by Molmil](/molmil-images/mine/5wj5) | |
8U3E
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![BU of 8u3e by Molmil](/molmil-images/mine/8u3e) | |
8U3H
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![BU of 8u3h by Molmil](/molmil-images/mine/8u3h) | |
8U3F
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![BU of 8u3f by Molmil](/molmil-images/mine/8u3f) | |
8U3D
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![BU of 8u3d by Molmil](/molmil-images/mine/8u3d) | |
9AYB
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![BU of 9ayb by Molmil](/molmil-images/mine/9ayb) | |
8U3G
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![BU of 8u3g by Molmil](/molmil-images/mine/8u3g) | Structure of NAAG-bound Sialin | Descriptor: | ACETYL GROUP, ASPARTIC ACID, GLUTAMIC ACID, ... | Authors: | Schmiege, P, Li, X. | Deposit date: | 2023-09-07 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Structure of NAAG-bound Sialin To Be Published
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6E7P
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![BU of 6e7p by Molmil](/molmil-images/mine/6e7p) | cryo-EM structure of human TRPML1 with PI35P2 | Descriptor: | (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], Mucolipin-1 | Authors: | Schmiege, P, Li, X. | Deposit date: | 2018-07-27 | Release date: | 2018-11-28 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9, 2018
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6E7Y
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![BU of 6e7y by Molmil](/molmil-images/mine/6e7y) | cryo-EM structure of human TRPML1 with PI45P2 | Descriptor: | Mucolipin-1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Schmiege, P, Li, X. | Deposit date: | 2018-07-27 | Release date: | 2018-11-28 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9, 2018
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6E7Z
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![BU of 6e7z by Molmil](/molmil-images/mine/6e7z) | cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2 | Descriptor: | (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1 | Authors: | Schmiege, P, Li, X. | Deposit date: | 2018-07-27 | Release date: | 2018-11-28 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9, 2018
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8DKE
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8DKW
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![BU of 8dkw by Molmil](/molmil-images/mine/8dkw) | |
8DKI
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![BU of 8dki by Molmil](/molmil-images/mine/8dki) | |
8DKX
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8DKM
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![BU of 8dkm by Molmil](/molmil-images/mine/8dkm) | |
5SUP
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![BU of 5sup by Molmil](/molmil-images/mine/5sup) | Crystal structure of the Sub2-Yra1 complex in association with RNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase SUB2, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Ren, Y, Schmiege, P, Blobel, G. | Deposit date: | 2016-08-03 | Release date: | 2017-01-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1. Elife, 6, 2017
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6E1H
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![BU of 6e1h by Molmil](/molmil-images/mine/6e1h) | Structure of 2:1 human Ptch1-Shh-N complex | Descriptor: | CALCIUM ION, PALMITIC ACID, Protein patched homolog 1, ... | Authors: | Qi, X, Li, X. | Deposit date: | 2018-07-09 | Release date: | 2018-08-29 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. Science, 362, 2018
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6UM2
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![BU of 6um2 by Molmil](/molmil-images/mine/6um2) | Structure of M-6-P/IGFII Receptor and IGFII complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II | Authors: | Wang, R, Qi, X, Li, X. | Deposit date: | 2019-10-08 | Release date: | 2020-02-26 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.32 Å) | Cite: | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Sci Adv, 6, 2020
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6UM1
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![BU of 6um1 by Molmil](/molmil-images/mine/6um1) | Structure of M-6-P/IGFII Receptor at pH 4.5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, ... | Authors: | Wang, R, Qi, X, Li, X. | Deposit date: | 2019-10-08 | Release date: | 2020-02-26 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Sci Adv, 6, 2020
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6OEV
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![BU of 6oev by Molmil](/molmil-images/mine/6oev) | Structure of human Patched1 in complex with native Sonic Hedgehog | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1, ... | Authors: | Qi, X, Li, X. | Deposit date: | 2019-03-27 | Release date: | 2019-04-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature, 560, 2018
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6OEU
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![BU of 6oeu by Molmil](/molmil-images/mine/6oeu) | Structure of human Patched1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 | Authors: | Qi, X, Li, X, Wang, J. | Deposit date: | 2019-03-27 | Release date: | 2019-04-10 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature, 560, 2018
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5U74
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![BU of 5u74 by Molmil](/molmil-images/mine/5u74) | Structure of human Niemann-Pick C1 protein | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, X. | Deposit date: | 2016-12-11 | Release date: | 2017-10-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.335 Å) | Cite: | 3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U73
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![BU of 5u73 by Molmil](/molmil-images/mine/5u73) | Crystal structure of human Niemann-Pick C1 protein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Niemann-Pick C1 protein, ... | Authors: | Li, X, Wang, J, Blobel, G. | Deposit date: | 2016-12-11 | Release date: | 2017-09-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.348 Å) | Cite: | 3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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