5U74

Structure of human Niemann-Pick C1 protein

Summary for 5U74

• Entry DOI: 10.2210/pdb5u74/pdb
• Related: 5U73
• Descriptor: Niemann-Pick C1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: npc1, membrane protein
• Biological source: Homo sapiens (Human)
• Cellular location: Late endosome membrane ; Multi-pass membrane protein : O15118
• Total number of polymer chains: 1
• Total formula weight: 145817.24

Authors

Li, X. (deposition date: 2016-12-11, release date: 2017-10-11, Last modification date: 2023-10-04)

• Primary citation: Li, X.,Lu, F.,Trinh, M.N.,Schmiege, P.,Seemann, J.,Wang, J.,Blobel, G.; 3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.; Proc. Natl. Acad. Sci. U.S.A., 114:9116-9121, 2017; PubMed: 28784760; DOI: 10.1073/pnas.1711716114

Experimental method

X-RAY DIFFRACTION (3.335 Å)