5U74

Structure of human Niemann-Pick C1 protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005319	molecular_function	lipid transporter activity
A	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	248
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	204
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	270
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	50
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26846330","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27238017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28784760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U74","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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