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8DKW

Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0

Summary for 8DKW
Entry DOI10.2210/pdb8dkw/pdb
EMDB information27492
DescriptorFab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin (3 entities in total)
Functional Keywordscystine, transporter, lysosome, membrane protein, membrane protein-transport protein complex, membrane protein/transport protein
Biological sourceMus musculus
More
Total number of polymer chains3
Total formula weight98331.95
Authors
Schmiege, P.,Li, X. (deposition date: 2022-07-06, release date: 2022-09-21, Last modification date: 2022-10-12)
Primary citationGuo, X.,Schmiege, P.,Assafa, T.E.,Wang, R.,Xu, Y.,Donnelly, L.,Fine, M.,Ni, X.,Jiang, J.,Millhauser, G.,Feng, L.,Li, X.
Structure and mechanism of human cystine exporter cystinosin.
Cell, 185:3739-3752.e18, 2022
Cited by
PubMed: 36113465
DOI: 10.1016/j.cell.2022.08.020
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.09 Å)
Structure validation

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