8DKE
Cryo-EM structure of cystinosin in a cytosol-open state
Summary for 8DKE
| Entry DOI | 10.2210/pdb8dke/pdb |
| EMDB information | 27488 |
| Descriptor | Isoform 2 of Cystinosin, Fab 3H5 Heavy chain, Fab 3H5 Kappa chain (3 entities in total) |
| Functional Keywords | cystine, transporter, lysosome, membrane protein, membrane protein-transport protein complex, membrane protein/transport protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 98316.87 |
| Authors | Schmiege, P.,Li, X. (deposition date: 2022-07-05, release date: 2022-09-21, Last modification date: 2022-10-12) |
| Primary citation | Guo, X.,Schmiege, P.,Assafa, T.E.,Wang, R.,Xu, Y.,Donnelly, L.,Fine, M.,Ni, X.,Jiang, J.,Millhauser, G.,Feng, L.,Li, X. Structure and mechanism of human cystine exporter cystinosin. Cell, 185:3739-3752.e18, 2022 Cited by PubMed: 36113465DOI: 10.1016/j.cell.2022.08.020 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.18 Å) |
Structure validation
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