6E1H

Structure of 2:1 human Ptch1-Shh-N complex

Summary for 6E1H

• Entry DOI: 10.2210/pdb6e1h/pdb
• EMDB information: 8955
• Descriptor: Protein patched homolog 1, Sonic hedgehog protein, ZINC ION, ... (5 entities in total)
• Functional Keywords: tumor suppressor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 341424.84

Authors

Qi, X.,Li, X. (deposition date: 2018-07-09, release date: 2018-08-29, Last modification date: 2023-02-22)

• Primary citation: Qi, X.,Schmiege, P.,Coutavas, E.,Li, X.; Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.; Science, 362:-, 2018; PubMed: 30139912; DOI: 10.1126/science.aas8843

Experimental method

ELECTRON MICROSCOPY (3.5 Å)