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1MH9
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BU of 1mh9 by Molmil
Crystal Structure Analysis of deoxyribonucleotidase
分子名称: MAGNESIUM ION, PHOSPHATE ION, deoxyribonucleotidase
著者Rinaldo-Matthis, A, Rampazzo, C, Reichard, P, Bianchi, V, Nordlund, P.
登録日2002-08-19
公開日2002-10-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a human mitochondrial deoxyribonucleotidase.
Nat.Struct.Biol., 9, 2002
3HKK
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BU of 3hkk by Molmil
Structure of human Leukotriene C4 synthase in complex with glutathione sulfonate
分子名称: GLUTATHIONE SULFONIC ACID, Leukotriene C4 synthase, PALMITIC ACID, ...
著者Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2009-05-24
公開日2010-05-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Pre-steady state kinetics of human Leukotriene C4 synthase
To be Published
1Q91
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BU of 1q91 by Molmil
Crystal structure of human mitochondrial deoxyribonucleotidase in complex with the inhibitor DPB-T
分子名称: (S)-1-[2'-DEOXY-3',5'-O-(1-PHOSPHONO)BENZYLIDENE-B-D-THREO-PENTOFURANOSYL]THYMINE, 5(3)-deoxyribonucleotidase, MAGNESIUM ION, ...
著者Rinaldo-Matthis, A, Rampazzo, C, Balzarini, J, Reichard, P, Bianchi, V, Nordlund, P.
登録日2003-08-22
公開日2004-04-20
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors
Mol.Pharmacol., 65, 2004
1Q92
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Crystal structure of human mitochondrial deoxyribonucleotidase in complex with the inhibitor PMcP-U
分子名称: 5(3)-deoxyribonucleotidase, GLYCEROL, MAGNESIUM ION, ...
著者Rinaldo-Matthis, A, Rampazzo, C, Balzarini, J, Reichard, P, Bianchi, V, Nordlund, P.
登録日2003-08-22
公開日2004-04-20
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors
Mol.Pharmacol., 65, 2004
2I4T
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BU of 2i4t by Molmil
Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with Imm-A
分子名称: 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, PHOSPHATE ION, Trichomonas vaginalis purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Schramm, V.L, Almo, S.C.
登録日2006-08-22
公開日2007-06-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.
Biochemistry, 46, 2007
2ISC
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BU of 2isc by Molmil
Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A
分子名称: (3R,4R)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-OL, PHOSPHATE ION, purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2006-10-17
公開日2007-06-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues
Biochemistry, 46, 2007
2Q7O
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BU of 2q7o by Molmil
Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2007-06-07
公開日2008-01-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.
J.Am.Chem.Soc., 130, 2008
2AC7
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BU of 2ac7 by Molmil
Crystal structure of Adenosine Phosphorylase from Bacillus cereus with adenosine bound in the active site
分子名称: ADENOSINE, Purine nucleoside phosphorylase, SULFATE ION
著者Rinaldo-Matthis, A, Allegrini, S, Sgarrella, F.
登録日2005-07-18
公開日2006-07-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Adenosine Phosphorylase from Bacillus cereus
To be Published
3LEO
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BU of 3leo by Molmil
Structure of human Leukotriene C4 synthase mutant R31Q in complex with glutathione
分子名称: DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, GLYCEROL, ...
著者Niegowski, D, Martinez-Molina, D, Rinaldo-Matthis, A, Nordlund, P, Haeggstrom, J.
登録日2010-01-15
公開日2010-10-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
J.Biol.Chem., 285, 2010
2OC9
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Crystal structure of human purine nucleoside phosphorylase mutant H257G with Imm-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2006-12-20
公開日2007-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase
Biochemistry, 46, 2007
2OC4
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Crystal structure of human purine nucleoside phosphorylase mutant H257D with Imm-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2006-12-20
公開日2007-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase
Biochemistry, 46, 2007
2ON6
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BU of 2on6 by Molmil
Crystal structure of human purine nucleoside phosphorylase mutant H257F with Imm-H
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Murkin, A.S, Almo, S.C, Schramm, V.L.
登録日2007-01-23
公開日2007-05-22
最終更新日2022-10-05
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase
Biochemistry, 46, 2007
2P4S
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BU of 2p4s by Molmil
Structure of Purine Nucleoside Phosphorylase from Anopheles gambiae in complex with DADMe-ImmH
分子名称: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase
著者Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2007-03-13
公開日2008-01-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition.
Biochemistry, 46, 2007
2I7D
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BU of 2i7d by Molmil
Structure of Human cytosolic deoxyribonucleotidase in complex with deoxyuridine, AlF4 and Mg2+
分子名称: 2'-DEOXYURIDINE, 5'(3')-deoxyribonucleotidase, cytosolic type, ...
著者Rinaldo-Matthis, A, Wallden, K, Nordlund, P.
登録日2006-08-30
公開日2007-10-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structures of Human and Murine cytosolic deoxyribonucleotidase: Insights into substrate specificity and catalysis
To be Published
5HV9
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BU of 5hv9 by Molmil
Human LTC4S mutant-S36E
分子名称: GLUTATHIONE, Leukotriene C4 synthase, SULFATE ION
著者Thulasingam, M, Ahmad, H.R.S, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2016-01-28
公開日2016-07-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
J.Biol.Chem., 291, 2016
3U9W
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Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Niegowski, D, Thunnissen, M, Tholander, F, Rinaldo-Matthis, A, Muroya, A, Haeggstrom, J.Z.
登録日2011-10-20
公開日2012-10-24
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
To be Published
3K8O
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BU of 3k8o by Molmil
Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH
分子名称: 7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE, Purine nucleoside phosphorylase, SULFATE ION
著者Ho, M, Rinaldo-matthis, A, Almo, S.C, Schramm, V.L.
登録日2009-10-14
公開日2010-03-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-Immucillin H
Proc.Natl.Acad.Sci.USA, 2010
1RSR
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azide complex of the diferrous F208A mutant R2 subunit of ribonucleotide reductase
分子名称: AZIDE ION, FE (II) ION, MERCURY (II) ION, ...
著者Andersson, M.E, Hogbom, M, Rinaldo-Matthis, A, Andersson, K.K, Sjoberg, B.M, Nordlund, P.
登録日2003-12-10
公開日2003-12-23
最終更新日2021-11-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Crystal Structure of an Azide Complex of the Diferrous R2 Subunit of Ribonucleotide Reductase Displays a Novel Carboxylate Shift with Important Mechanistic Implications for Diiron-Catalyzed Oxygen Activation
J.Am.Chem.Soc., 121, 1999
4L2L
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BU of 4l2l by Molmil
Human Leukotriene A4 Hydrolase complexed with ligand 4-(4-benzylphenyl)thiazol-2-amine
分子名称: 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETATE ION, Leukotriene A-4 hydrolase, ...
著者Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2013-06-04
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.648 Å)
主引用文献Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proc.Natl.Acad.Sci.USA, 111, 2014
4MKT
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Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue and 4-(4-benzylphenyl)thiazol-2-amine
分子名称: 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ACETIC ACID, ...
著者Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2013-09-05
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.618 Å)
主引用文献Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proc.Natl.Acad.Sci.USA, 111, 2014
4MS6
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Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue
分子名称: 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, ACETIC ACID, Leukotriene A-4 hydrolase, ...
著者Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2013-09-18
公開日2014-03-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proc.Natl.Acad.Sci.USA, 111, 2014
6SSR
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BU of 6ssr by Molmil
Crystal structure of Human Microsomal Glutathione S-Transferase 2 at 3.8 Angstroms resolution
分子名称: Microsomal glutathione S-transferase 2
著者Thulasingam, M, Nji, E, Rinaldo-Matthis, A, Haeggstrom, J.Z.
登録日2019-09-09
公開日2021-02-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
4GAA
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Structure of Leukotriene A4 hydrolase from Xenopus laevis complexed with inhibitor bestatin
分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, MGC78867 protein, ZINC ION
著者Stsiapanava, A, Kumar, R.B, Haeggstrom, J.Z, Rinaldo-Matthis, A.
登録日2012-07-25
公開日2013-06-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Biochim.Biophys.Acta, 1844, 2014
3DP9
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Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with butylthio-DADMe-Immucillin A
分子名称: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, IODIDE ION, MTA/SAH nucleosidase
著者Ho, M, Gutierrez, J.A, Crowder, T, Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L.
登録日2008-07-07
公開日2009-03-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
Nat.Chem.Biol., 5, 2009
3EEI
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Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A
分子名称: (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase
著者Ho, M, Rinaldo-matthis, A, Brown, R.L, Norris, G.E, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L.
登録日2008-09-04
公開日2009-09-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A
To be Published

 

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