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PDB: 33 results

2ACY
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BU of 2acy by Molmil
ACYL-PHOSPHATASE (COMMON TYPE) FROM BOVINE TESTIS
Descriptor: ACYLPHOSPHATASE, CHLORIDE ION, SULFATE ION
Authors:Thunnissen, M.M.G.M, Nordlund, P.
Deposit date:1996-11-08
Release date:1997-11-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of common type acylphosphatase from bovine testis.
Structure, 5, 1997
3CHQ
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BU of 3chq by Molmil
Crystal structure of leukotriene a4 hydrolase in complex with N5-[4-(phenylmethoxy)phenyl]-L-glutamine
Descriptor: (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:Thunnissen, M.M.G.M, Adler, M, Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHR
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BU of 3chr by Molmil
Crystal structure of leukotriene A4 hydrolase in complex with 4-amino-N-[4-(phenylmethoxy)phenyl]-butanamide
Descriptor: 4-amino-N-[4-(benzyloxy)phenyl]butanamide, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:Thunnissen, M.M.G.M, Adler, M, Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHS
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BU of 3chs by Molmil
Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid
Descriptor: (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:Thunnissen, M.M.G.M, Adler, M, Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHO
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BU of 3cho by Molmil
Crystal structure of leukotriene a4 hydrolase in complex with 2-amino-N-[4-(phenylmethoxy)phenyl]-acetamide
Descriptor: ACETATE ION, Leukotriene A-4 hydrolase, N-[4-(benzyloxy)phenyl]glycinamide, ...
Authors:Thunnissen, M.M.G.M, Adler, M, Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHP
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BU of 3chp by Molmil
Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid
Descriptor: (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid, ACETATE ION, IMIDAZOLE, ...
Authors:Thunnissen, M.M.G.M, Adler, M, Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
1HS6
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BU of 1hs6 by Molmil
STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ...
Authors:Thunnissen, M.M.G.M, Nordlund, P.N, Haeggstrom, J.Z.
Deposit date:2000-12-24
Release date:2001-06-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nat.Struct.Biol., 8, 2001
2VJ8
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BU of 2vj8 by Molmil
Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor
Descriptor: 6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID), ACETATE ION, IMIDAZOLE, ...
Authors:Thunnissen, M.M.G.M, Andersson, B, Wong, C.-H, Samuelsson, B, Haeggstrom, J.Z.
Deposit date:2007-12-07
Release date:2008-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors
Faseb J., 16, 2002
5P2P
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BU of 5p2p by Molmil
X-RAY STRUCTURE OF PHOSPHOLIPASE A2 COMPLEXED WITH A SUBSTRATE-DERIVED INHIBITOR
Descriptor: CALCIUM ION, PHOSPHOLIPASE A2, PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER
Authors:Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J.
Deposit date:1990-09-01
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor.
Nature, 347, 1990
2R59
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BU of 2r59 by Molmil
Leukotriene A4 hydrolase complexed with inhibitor RB3041
Descriptor: ACETIC ACID, Leukotriene A-4 hydrolase, N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ...
Authors:Tholander, F, Haeggstrom, J.Z, Thunnissen, M, Muroya, A, Roques, B.P, Fournie-Zaluski, M.C.
Deposit date:2007-09-03
Release date:2008-08-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
1GW6
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BU of 1gw6 by Molmil
STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ...
Authors:Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Samuelsson, B, Haeggstrom, J.Z.
Deposit date:2002-03-07
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375
Proc.Natl.Acad.Sci.USA, 99, 2002
1SQM
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BU of 1sqm by Molmil
STRUCTURE OF [R563A] LEUKOTRIENE A4 HYDROLASE
Descriptor: ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ...
Authors:Tholander, F.O.T, Rudberg, P.C, Thunnissen, M.M.G.M, Haeggstrom, J.Z.
Deposit date:2004-03-19
Release date:2004-08-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates
J.Biol.Chem., 279, 2004
2PHI
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BU of 2phi by Molmil
A LARGE CONFORMATIONAL CHANGE IS FOUND IN THE CRYSTAL STRUCTURE OF THE PORCINE PANCREATIC PHOSPHOLIPASE A2 POINT MUTANT F63V
Descriptor: CALCIUM ION, PHOSPHOLIPASE A2
Authors:Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J.
Deposit date:1993-04-08
Release date:1993-07-15
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a porcine pancreatic phospholipase A2 mutant. A large conformational change caused by the F63V point mutation.
J.Mol.Biol., 232, 1993
1IIB
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BU of 1iib by Molmil
CRYSTAL STRUCTURE OF IIBCELLOBIOSE FROM ESCHERICHIA COLI
Descriptor: ENZYME IIB OF THE CELLOBIOSE-SPECIFIC PHOSPHOTRANSFERASE SYSTEM
Authors:Van Montfort, R.L.M, Pijning, T, Kalk, K.H, Reizer, J, Saier, M.H, Thunnissen, M.M.G.M, Robillard, G.T, Dijkstra, B.W.
Deposit date:1996-12-23
Release date:1997-12-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of an energy-coupling protein from bacteria, IIBcellobiose, reveals similarity to eukaryotic protein tyrosine phosphatases.
Structure, 5, 1997
3B7S
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BU of 3b7s by Molmil
[E296Q]LTA4H in complex with RSR substrate
Descriptor: ACETIC ACID, GLYCEROL, Leukotriene A-4 hydrolase, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.465 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3B7U
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BU of 3b7u by Molmil
Leukotriene A4 Hydrolase Complexed with KELatorphan
Descriptor: ACETIC ACID, IMIDAZOLE, Leukotriene A-4 hydrolase, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3B7R
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BU of 3b7r by Molmil
Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040
Descriptor: IMIDAZOLE, Leukotriene A-4 hydrolase, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3B7T
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BU of 3b7t by Molmil
[E296Q]LTA4H in complex with Arg-Ala-Arg substrate
Descriptor: IMIDAZOLE, Leukotriene A-4 hydrolase, RAR peptide, ...
Authors:Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
4BWE
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BU of 4bwe by Molmil
Crystal structure of C-terminally truncated glypican-1 after controlled dehydration to 86 percent relative humidity
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Glypican-1
Authors:Awad, W, Svensson Birkedal, G, Thunnissen, M.M.G.M, Mani, K, Logan, D.T.
Deposit date:2013-07-01
Release date:2013-12-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration.
Acta Crystallogr. D Biol. Crystallogr., 69, 2013
3P2P
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BU of 3p2p by Molmil
ENHANCED ACTIVITY AND ALTERED SPECIFICITY OF PHOSPHOLIPASE A2 BY DELETION OF A SURFACE LOOP
Descriptor: CALCIUM ION, PHOSPHOLIPASE A2
Authors:Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J.
Deposit date:1989-11-29
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop.
Science, 244, 1989
3ZH7
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BU of 3zh7 by Molmil
The structure of crystal form II of Haemophilus influenzae protein E
Descriptor: 1,2-ETHANEDIOL, PROTEIN E
Authors:Singh, B, Al-Jubair, T, Riesbeck, K, Thunnissen, M.M.G.M.
Deposit date:2012-12-20
Release date:2013-04-17
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:The Unique Structure of Haemophilus Influenzae Protein E Reveals Multiple Binding Sites for Host Factors.
Infect.Immun., 81, 2013
3ZH6
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BU of 3zh6 by Molmil
The structure of Haemophilus influenzae Se_Met form of protein E
Descriptor: PROTEIN E
Authors:Singh, B, Al-Jubair, T, Riesbeck, K, Thunnissen, M.M.G.M.
Deposit date:2012-12-20
Release date:2013-03-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:The Unique Structure of Haemophilus Influenzae Protein E Reveals Multiple Binding Sites for Host Factors.
Infect.Immun., 81, 2013
3ZH5
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BU of 3zh5 by Molmil
The structure of Haemophilus influenzae protein E
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, PROTEIN E
Authors:Singh, B, Al-Jubair, T, Riesbeck, K, Thunnissen, M.M.G.M.
Deposit date:2012-12-20
Release date:2013-03-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:The Unique Structure of Haemophilus Influenzae Protein E Reveals Multiple Binding Sites for Host Factors.
Infect.Immun., 81, 2013
2W65
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BU of 2w65 by Molmil
Anti citrullinated Collagen type 2 antibody acc4 in complex with a citrullinated peptide
Descriptor: ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4, COLLAGEN DERIVED PEPTIDE PCII-CIT1, SULFATE ION
Authors:Uysal, H, Bockermann, R, Nandakumar, K.S, Sehnert, B, Bajtner, E, Engstrom, A, Serre, G, Burkhardt, H, Thunnissen, M.M.G.M, Holmdahl, R.
Deposit date:2008-12-17
Release date:2009-02-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
J. Exp. Med., 206, 2009
1H19
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BU of 1h19 by Molmil
STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
Descriptor: ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ...
Authors:Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Haeggstrom, J.Z.
Deposit date:2002-07-04
Release date:2002-08-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms
J.Biol.Chem., 277, 2002

 

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