3CHS
Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid
Summary for 3CHS
Entry DOI | 10.2210/pdb3chs/pdb |
Related | 1GW6 1H19 1HS6 1SQM 2VJ8 3CHO 3CHP 3CHQ 3CHR |
Descriptor | Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total) |
Functional Keywords | epoxide hydrolase, alpha-beta protein, leukotriene biosynthesis, metalloprotease, inhibitor complex, alternative splicing, cytoplasm, metal-binding, multifunctional enzyme, zinc, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 70244.78 |
Authors | Thunnissen, M.M.G.M.,Adler, M.,Whitlow, M. (deposition date: 2008-03-10, release date: 2008-04-22, Last modification date: 2024-02-21) |
Primary citation | Kirkland, T.A.,Adler, M.,Bauman, J.G.,Chen, M.,Haeggstrom, J.Z.,King, B.,Kochanny, M.J.,Liang, A.M.,Mendoza, L.,Phillips, G.B.,Thunnissen, M.,Trinh, L.,Whitlow, M.,Ye, B.,Ye, H.,Parkinson, J.,Guilford, W.J. Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg.Med.Chem., 16:4963-4983, 2008 Cited by PubMed: 18394906DOI: 10.1016/j.bmc.2008.03.042 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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