3CHS

Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid

Summary for 3CHS

Entry DOI	10.2210/pdb3chs/pdb
Related	1GW6 1H19 1HS6 1SQM 2VJ8 3CHO 3CHP 3CHQ 3CHR
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total)
Functional Keywords	epoxide hydrolase, alpha-beta protein, leukotriene biosynthesis, metalloprotease, inhibitor complex, alternative splicing, cytoplasm, metal-binding, multifunctional enzyme, zinc, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	70244.78
Authors	Thunnissen, M.M.G.M.,Adler, M.,Whitlow, M. (deposition date: 2008-03-10, release date: 2008-04-22, Last modification date: 2024-02-21)
Primary citation	Kirkland, T.A.,Adler, M.,Bauman, J.G.,Chen, M.,Haeggstrom, J.Z.,King, B.,Kochanny, M.J.,Liang, A.M.,Mendoza, L.,Phillips, G.B.,Thunnissen, M.,Trinh, L.,Whitlow, M.,Ye, B.,Ye, H.,Parkinson, J.,Guilford, W.J. Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg.Med.Chem., 16:4963-4983, 2008 Cited by PubMed: 18394906 DOI: 10.1016/j.bmc.2008.03.042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation