1GW6

STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT

Summary for 1GW6

• Entry DOI: 10.2210/pdb1gw6/pdb
• Related: 1HS6
• Descriptor: LEUKOTRIENE A-4 HYDROLASE, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, ... (7 entities in total)
• Functional Keywords: hydrolase, mutagenesis studies, alpha-beta protein
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P09960
• Total number of polymer chains: 1
• Total formula weight: 69906.74

Authors

Rudberg, P.C.,Tholander, F.,Thunnissen, M.M.G.M.,Samuelsson, B.,Haeggstrom, J.Z. (deposition date: 2002-03-07, release date: 2003-03-06, Last modification date: 2023-12-13)

• Primary citation: Rudberg, P.C.,Tholander, F.,Thunnissen, M.M.G.M.,Samuelsson, B.,Haeggstrom, J.Z.; Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375; Proc.Natl.Acad.Sci.USA, 99:4215-, 2002; PubMed: 11917124; DOI: 10.1073/PNAS.072090099

Experimental method

X-RAY DIFFRACTION (2.2 Å)