3B7T

[E296Q]LTA4H in complex with Arg-Ala-Arg substrate

Summary for 3B7T

Related2R59 3B7R 3B7S 3B7U
DescriptorLeukotriene A-4 hydrolase, RAR peptide, ZINC ION, ... (6 entities in total)
Functional Keywordstransition state, analogue peptide, hydrolysis, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, zinc, tripeptide substrate
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight70944.72
Authors
Tholander, F.,Haeggstrom, J.,Thunnissen, M.,Muroya, A.,Roques, B.-P.,Fournie-Zaluski, M.-C. (deposition date: 2007-10-31, release date: 2008-09-16, Last modification date: 2019-11-20)
Primary citation
Tholander, F.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C.,Thunnissen, M.M.,Haeggstrom, J.Z.
Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15:920-929, 2008
PubMed: 18804029 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2008.07.018
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2708 0.3% 1.5% 6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-10-28