3B7S

[E296Q]LTA4H in complex with RSR substrate

Summary for 3B7S

• Entry DOI: 10.2210/pdb3b7s/pdb
• Related: 2R59 3B7R 3B7T 3B7U
• Descriptor: Leukotriene A-4 hydrolase, RSR peptide, ZINC ION, ... (7 entities in total)
• Functional Keywords: transition state, analogue peptide, hydrolysis, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, tripeptide substrate
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 70870.74

Authors

Tholander, F.,Haeggstrom, J.,Thunnissen, M.,Muroya, A.,Roques, B.-P.,Fournie-Zaluski, M.-C. (deposition date: 2007-10-31, release date: 2008-09-16, Last modification date: 2023-08-30)

• Primary citation: Tholander, F.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C.,Thunnissen, M.M.,Haeggstrom, J.Z.; Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.; Chem.Biol., 15:920-929, 2008; PubMed: 18804029; DOI: 10.1016/j.chembiol.2008.07.018

Experimental method

X-RAY DIFFRACTION (1.465 Å)