1Q92

Crystal structure of human mitochondrial deoxyribonucleotidase in complex with the inhibitor PMcP-U

Summary for 1Q92

Entry DOI	10.2210/pdb1q92/pdb
Related	1MH9 1Q91
Descriptor	5(3)-deoxyribonucleotidase, MAGNESIUM ION, {[(1R,2S)-2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)CYCLOPENTYL]OXY}METHYLPHOSPHONIC ACID, ... (5 entities in total)
Functional Keywords	alpha-beta rossman fold, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion: Q9NPB1
Total number of polymer chains	1
Total formula weight	23247.73
Authors	Rinaldo-Matthis, A.,Rampazzo, C.,Balzarini, J.,Reichard, P.,Bianchi, V.,Nordlund, P. (deposition date: 2003-08-22, release date: 2004-04-20, Last modification date: 2023-10-25)
Primary citation	Rinaldo-Matthis, A.,Rampazzo, C.,Balzarini, J.,Reichard, P.,Bianchi, V.,Nordlund, P. Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors Mol.Pharmacol., 65:860-867, 2004 Cited by PubMed: 15044615 DOI: 10.1124/mol.65.4.860 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation