1Q92
Crystal structure of human mitochondrial deoxyribonucleotidase in complex with the inhibitor PMcP-U
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1003 |
| Chain | Residue |
| A | ASP41 |
| A | ASP43 |
| A | ASP176 |
| A | HOH2008 |
| A | HOH2011 |
| A | HOH2135 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE DRM A 1001 |
| Chain | Residue |
| A | PHE75 |
| A | TRP76 |
| A | VAL77 |
| A | SER131 |
| A | ILE133 |
| A | LYS165 |
| A | ARG177 |
| A | HOH2008 |
| A | HOH2011 |
| A | HOH2015 |
| A | HOH2022 |
| A | HOH2047 |
| A | HOH2135 |
| A | HOH2151 |
| A | HOH2232 |
| A | HOH2245 |
| A | ASP41 |
| A | ASP43 |
| A | PHE49 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 2001 |
| Chain | Residue |
| A | ARG73 |
| A | GLY74 |
| A | HIS198 |
| A | ASN199 |
| A | GLN200 |
| A | HIS201 |
| A | LEU202 |
| A | HOH2302 |
| A | HOH2304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15044615","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q91","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15044615","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q91","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12352955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12352955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16004879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z4K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1q91 |
| Chain | Residue | Details |
| A | ASP43 | |
| A | ASP41 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 812 |
| Chain | Residue | Details |
| A | ASP41 | covalently attached, metal ligand, nucleofuge, nucleophile |
| A | ASP43 | metal ligand |
| A | ASP176 | metal ligand |
