4L2L

Human Leukotriene A4 Hydrolase complexed with ligand 4-(4-benzylphenyl)thiazol-2-amine

Summary for 4L2L

• Entry DOI: 10.2210/pdb4l2l/pdb
• Related: 3U9W 4DPR
• Descriptor: Leukotriene A-4 hydrolase, ZINC ION, 4-(4-benzylphenyl)-1,3-thiazol-2-amine, ... (6 entities in total)
• Functional Keywords: metalloprotein, hydrolase, protease, zinc binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P09960
• Total number of polymer chains: 1
• Total formula weight: 70565.03

Authors

Stsiapanava, A.,Rinaldo-Matthis, A.,Haeggstrom, J.Z. (deposition date: 2013-06-04, release date: 2014-03-12, Last modification date: 2023-09-20)

• Primary citation: Stsiapanava, A.,Olsson, U.,Wan, M.,Kleinschmidt, T.,Rutishauser, D.,Zubarev, R.A.,Samuelsson, B.,Rinaldo-Matthis, A.,Haeggstrom, J.Z.; Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.; Proc.Natl.Acad.Sci.USA, 111:4227-4232, 2014; PubMed: 24591641; DOI: 10.1073/pnas.1402136111

Experimental method

X-RAY DIFFRACTION (1.648 Å)