7SR8
| Molecular mechanism of the the wake-promoting agent TAK-925 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... | Authors: | Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. | Deposit date: | 2021-11-08 | Release date: | 2022-06-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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7SUB
| 3-oxoacyl-ACP reductase FabG | Descriptor: | 3-oxoacyl-reductase, GLYCEROL | Authors: | Thomas, L.M, Karr, E.A, Dinh, D.M. | Deposit date: | 2021-11-16 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Crystal structure of a putative 3-hydroxypimelyl-CoA dehydrogenase, Hcd1, from Syntrophus aciditrophicus strain SB at 1.78 A resolution Acta Crystallogr.,Sect.F, 79, 2023
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7TH8
| Chickpea (Cicer arientinum) nodule-specific cysteine-rich peptide NCR13: Solution NMR structure of the isomer with C4:C10, C15:C30, and C23:C28 disulfide bonds | Descriptor: | Nodule cysteine-rich protein 13 | Authors: | Buchko, G.W, Zhou, M, Shah, D.M, Velivelli, S.L.S. | Deposit date: | 2022-01-10 | Release date: | 2022-02-02 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Chickpea (Cicer arientinum) nodule-specific cysteine-rich peptide NCR13: Solution NMR structure of the isomer with C4:C10, C15:C30, and C23:C28 disulfide bonds To Be Published
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7TRK
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo | Descriptor: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-29 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRS
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine | Descriptor: | ACETYLCHOLINE, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRQ
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 | Descriptor: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRP
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7W9A
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8EJC
| Structure of FFAR1-Gq complex bound to TAK-875 | Descriptor: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | Deposit date: | 2022-09-16 | Release date: | 2023-05-24 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJK
| Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc | Descriptor: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | Deposit date: | 2022-09-17 | Release date: | 2023-05-24 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EIT
| Structure of FFAR1-Gq complex bound to DHA | Descriptor: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | Authors: | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | Deposit date: | 2022-09-15 | Release date: | 2023-05-24 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular mechanism of fatty acid activation of FFAR1. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F7B
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F75
| LRRC8A(T48D):C conformation 2 LRR focus | Descriptor: | Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F7E
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F77
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F74
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F7D
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F79
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F7J
| LRRC8A(T48D):C conformation 2 top focus | Descriptor: | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562 | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (4.32 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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6XQR
| OXA-48 bound by Compound 2.2 | Descriptor: | Beta-lactamase, CHLORIDE ION, [1,1'-biphenyl]-4,4'-disulfonic acid | Authors: | Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T. | Deposit date: | 2020-07-10 | Release date: | 2021-12-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. Acs Infect Dis., 7, 2021
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6Y8O
| Mycobacterium smegmatis GyrB 22kDa ATPase sub-domain in complex with novobiocin | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DNA gyrase subunit B, ... | Authors: | Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A. | Deposit date: | 2020-03-05 | Release date: | 2020-08-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase. J.Antimicrob.Chemother., 75, 2020
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6Y93
| Crystal structure of the DNA-binding domain of the Nucleoid Occlusion Factor (Noc) complexed to the Noc-binding site (NBS) | Descriptor: | Noc Binding Site (NBS), Nucleoid occlusion protein | Authors: | Jalal, A.S.B, Tran, N.T, Stevenson, C.E.M, Chan, E, Lo, R, Tan, X, Noy, A, Lawson, D.M, Le, T.B.K. | Deposit date: | 2020-03-06 | Release date: | 2020-08-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Diversification of DNA-Binding Specificity by Permissive and Specificity-Switching Mutations in the ParB/Noc Protein Family. Cell Rep, 32, 2020
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6Y8L
| Mycobacterium thermoresistibile GyrB21 in complex with novobiocin | Descriptor: | 1,2-ETHANEDIOL, DNA gyrase subunit B, NOVOBIOCIN, ... | Authors: | Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A. | Deposit date: | 2020-03-05 | Release date: | 2020-08-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase. J.Antimicrob.Chemother., 75, 2020
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8F5D
| Architecture of the MurE-MurF ligase bacterial cell wall biosynthesis complex | Descriptor: | Multifunctional fusion protein, SULFATE ION | Authors: | Shirakawa, K.T, Sala, F.A, Miyachiro, M.M, Job, V, Trindade, D.M, Dessen, A. | Deposit date: | 2022-11-14 | Release date: | 2023-06-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Architecture and genomic arrangement of the MurE-MurF bacterial cell wall biosynthesis complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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6Y8N
| Mycobacterium thermoresistibile GyrB21 in complex with Redx03863 | Descriptor: | 1,2-ETHANEDIOL, 4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine, DNA gyrase subunit B, ... | Authors: | Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A. | Deposit date: | 2020-03-05 | Release date: | 2020-08-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase. J.Antimicrob.Chemother., 75, 2020
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