8F77
LRRC8A(T48D):C conformation 2 top focus
Summary for 8F77
Entry DOI | 10.2210/pdb8f77/pdb |
Related | 8F74 8F75 8F79 8F7B 8F7D 8F7E 8F7J |
EMDB information | 28894 28895 28897 28898 28901 28903 28904 28905 |
Descriptor | Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... (4 entities in total) |
Functional Keywords | ion channel, volume-regulation, membrane protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 632505.53 |
Authors | Kern, D.M.,Brohawn, S.G. (deposition date: 2022-11-18, release date: 2023-03-08, Last modification date: 2023-07-05) |
Primary citation | Kern, D.M.,Bleier, J.,Mukherjee, S.,Hill, J.M.,Kossiakoff, A.A.,Isacoff, E.Y.,Brohawn, S.G. Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30:841-852, 2023 Cited by PubMed: 36928458DOI: 10.1038/s41594-023-00944-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.15 Å) |
Structure validation
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