8F77

LRRC8A(T48D):C conformation 2 top focus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562	polymer	911	105544.1	5	UniProt (Q80WG5) UniProt (P0ABE7) Pfam (PF12534) Pfam (PF07361) Pfam (PF13855) In PDB	Mus musculus (house mouse)	Leucine-rich repeat-containing protein 8A,Protein ebouriffe,ebo,Cytochrome b-562
2	F	Volume-regulated anion channel subunit LRRC8C	polymer	813	93624.6	1	UniProt (Q8R502) Pfam (PF12534) Pfam (PF13855) In PDB	Mus musculus (house mouse)	Factor for adipocyte differentiation 158,Leucine-rich repeat-containing protein 8C
3	A, B, C, D, E...	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine	non-polymer		744.0	15	Chemie (PEE)
4		water	water		18.0	6	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 1 - 68 (UniProt: Q80WG5)

PDB	External Database	Details
Asp 48	Thr 48	engineered mutation

A, B, C, D, E: 68 - 72 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 68	Met 29	conflict
Ile 72	His 124	conflict

A, B, C, D, E: 72 - 810 (UniProt: Q80WG5)

PDB	External Database	Details
Leu 72	Pro 90	conflict
Ser 811	-	expression tag
Asn 812	-	expression tag
Ser 813	-	expression tag
Leu 814	-	expression tag
Glu 815	-	expression tag
Val 816	-	expression tag
Leu 817	-	expression tag
Phe 818	-	expression tag
Gln 819	-	expression tag

F: 1 - 803 (UniProt: Q8R502)

PDB	External Database	Details
Ser 804	-	expression tag
Asn 805	-	expression tag
Ser 806	-	expression tag
Glu 807	-	expression tag
Asn 808	-	expression tag
Leu 809	-	expression tag
Tyr 810	-	expression tag
Phe 811	-	expression tag
Gln 812	-	expression tag
Gly 813	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	621345.0
Non-Polymers*	Number of molecules	15
	Total formula weight	11160.5
All*	Total formula weight	632505.5

*Water molecules are not included.