8F74

LRRC8A(T48D):C conformation 2 top focus

Summary for 8F74

• Entry DOI: 10.2210/pdb8f74/pdb
• EMDB information: 28894
• Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... (4 entities in total)
• Functional Keywords: ion channel, volume-regulation, membrane protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 632505.53

Authors

Kern, D.M.,Brohawn, S.G. (deposition date: 2022-11-18, release date: 2023-03-08, Last modification date: 2023-07-05)

• Primary citation: Kern, D.M.,Bleier, J.,Mukherjee, S.,Hill, J.M.,Kossiakoff, A.A.,Isacoff, E.Y.,Brohawn, S.G.; Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.; Nat.Struct.Mol.Biol., 30:841-852, 2023; PubMed: 36928458; DOI: 10.1038/s41594-023-00944-6

Experimental method

ELECTRON MICROSCOPY (3.1 Å)