6Y8N
Mycobacterium thermoresistibile GyrB21 in complex with Redx03863
Summary for 6Y8N
Entry DOI | 10.2210/pdb6y8n/pdb |
Related | 6Y8L |
Descriptor | DNA gyrase subunit B, 4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine, ZINC ION, ... (5 entities in total) |
Functional Keywords | binding sites, dna gyrase, inhibitors, , redx03863 iv, isomerase, dna binding protein |
Biological source | Mycolicibacterium thermoresistibile |
Total number of polymer chains | 2 |
Total formula weight | 43014.50 |
Authors | Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.,Lawson, D.M.,Maxwell, A. (deposition date: 2020-03-05, release date: 2020-08-12, Last modification date: 2024-01-24) |
Primary citation | Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.M.,Lawson, D.M.,Maxwell, A. Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase. J.Antimicrob.Chemother., 75:2835-2842, 2020 Cited by PubMed: 32728686DOI: 10.1093/jac/dkaa286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report