6Y8N

Mycobacterium thermoresistibile GyrB21 in complex with Redx03863

Summary for 6Y8N

• Entry DOI: 10.2210/pdb6y8n/pdb
• Related: 6Y8L
• Descriptor: DNA gyrase subunit B, 4-[(1~{S},5~{R})-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-6-fluoranyl-~{N}-methyl-2-(2-methylpyrimidin-5-yl)oxy-9~{H}-pyrimido[4,5-b]indol-8-amine, ZINC ION, ... (5 entities in total)
• Functional Keywords: binding sites, dna gyrase, inhibitors, , redx03863 iv, isomerase, dna binding protein
• Biological source: Mycolicibacterium thermoresistibile
• Total number of polymer chains: 2
• Total formula weight: 43014.50

Authors

Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.,Lawson, D.M.,Maxwell, A. (deposition date: 2020-03-05, release date: 2020-08-12, Last modification date: 2024-01-24)

Primary citation

Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.M.,Lawson, D.M.,Maxwell, A.
Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
J.Antimicrob.Chemother., 75:2835-2842, 2020

PubMed Abstract: To evaluate the efficacy of two novel compounds against mycobacteria and determine the molecular basis of their action on DNA gyrase using structural and mechanistic approaches.

PubMed: 32728686
DOI: 10.1093/jac/dkaa286

Experimental method

X-RAY DIFFRACTION (1.5 Å)