6Y8O

Mycobacterium smegmatis GyrB 22kDa ATPase sub-domain in complex with novobiocin

Summary for 6Y8O

• Entry DOI: 10.2210/pdb6y8o/pdb
• Related: 6Y8L 6Y8N
• Descriptor: DNA gyrase subunit B, NOVOBIOCIN, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: binding sites, dna gyrase, inhibitors, , novobiocin iv, isomerase, dna binding protein
• Biological source: Mycolicibacterium smegmatis
• Total number of polymer chains: 2
• Total formula weight: 54442.51

Authors

Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.,Lawson, D.M.,Maxwell, A. (deposition date: 2020-03-05, release date: 2020-08-12, Last modification date: 2024-01-24)

• Primary citation: Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.M.,Lawson, D.M.,Maxwell, A.; Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.; J.Antimicrob.Chemother., 75:2835-2842, 2020; PubMed: 32728686; DOI: 10.1093/jac/dkaa286

Experimental method

X-RAY DIFFRACTION (1.6 Å)