5YW7
 
 | |
5YWA
 | |
6BV2
 | | Crystal structure of porcine aminopeptidase-N with Isoleucine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, L, Lin, Y.-L, Li, F. | | Deposit date: | 2017-12-12 | | Release date: | 2018-01-17 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
|
|
6BV4
 | | Crystal structure of porcine aminopeptidase-N with Methionine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, L, Lin, Y.-L, Li, F. | | Deposit date: | 2017-12-12 | | Release date: | 2018-01-10 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
|
|
6BUY
 | | Crystal structure of porcine aminopeptidase-N with Glycine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, L, Lin, Y.-L, Li, F. | | Deposit date: | 2017-12-11 | | Release date: | 2018-01-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
|
|
6BV0
 | | Crystal structure of porcine aminopeptidase-N with Arginine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, L, Lin, Y.-L, Li, F. | | Deposit date: | 2017-12-12 | | Release date: | 2018-01-17 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
|
|
6BV1
 | | Crystal structure of porcine aminopeptidase-N with Aspartic acid | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, L, Lin, Y.-L, Li, F. | | Deposit date: | 2017-12-12 | | Release date: | 2018-01-17 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
|
|
6BV3
 | | Crystal structure of porcine aminopeptidase-N with Leucine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, L, Lin, Y.-L, Li, F. | | Deposit date: | 2017-12-12 | | Release date: | 2018-01-17 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
|
|
7CU3
 | | Structure of mammalian NALCN-FAM155A complex at 2.65 angstrom | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Sodium leak channel non-selective protein, ... | | Authors: | Chen, L, Kang, Y. | | Deposit date: | 2020-08-20 | | Release date: | 2020-11-18 | | Last modified: | 2021-06-02 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
Nat Commun, 11, 2020
|
|
7D3E
 | | Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dual oxidase 1, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Chen, L, Wu, J.X. | | Deposit date: | 2020-09-19 | | Release date: | 2020-12-09 | | Last modified: | 2021-06-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.
Nat Commun, 12, 2021
|
|
7D3F
 | | Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Dual oxidase 1, ... | | Authors: | Chen, L, Wu, J.X. | | Deposit date: | 2020-09-19 | | Release date: | 2020-12-09 | | Last modified: | 2021-06-23 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.
Nat Commun, 12, 2021
|
|
7D9R
 | | Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
|
|
7D9T
 | | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
|
|
7D9U
 | | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
|
|
7D9S
 | | Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
|
|
7DXC
 | | Structure of TRPC3 at 3.06 angstrom in low calcium state | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | | Authors: | Chen, L, Guo, W. | | Deposit date: | 2021-01-18 | | Release date: | 2022-02-02 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXB
 | | Structure of TRPC3 at 2.7 angstrom in high calcium state | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Chen, L, Guo, W. | | Deposit date: | 2021-01-18 | | Release date: | 2022-02-02 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXD
 | | Structure of TRPC3 at 3.9 angstrom in 1340 nM free calcium state | | Descriptor: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | | Authors: | Chen, L, Guo, W. | | Deposit date: | 2021-01-18 | | Release date: | 2022-01-19 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXG
 | | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | | Authors: | Chen, L, Guo, W. | | Deposit date: | 2021-01-18 | | Release date: | 2022-02-02 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXF
 | | Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Chen, L, Guo, W. | | Deposit date: | 2021-01-18 | | Release date: | 2022-02-02 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXE
 | |
7WDB
 | | Human TRPC5 channel in complex with riluzole | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, ... | | Authors: | Chen, L, Wei, M, Yang, Y. | | Deposit date: | 2021-12-21 | | Release date: | 2022-04-13 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structural identification of riluzole-binding site on human TRPC5.
Cell Discov, 8, 2022
|
|
7WIT
 | | Structure of SUR1 in complex with mitiglinide | | Descriptor: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | | Authors: | Chen, L, Wang, M.M. | | Deposit date: | 2022-01-04 | | Release date: | 2022-11-16 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Front Pharmacol, 13, 2022
|
|
7WMV
 | | Structure of human SGLT1-MAP17 complex bound with LX2761 | | Descriptor: | N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | | Authors: | Chen, L, Niu, Y, Cui, W. | | Deposit date: | 2022-01-17 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural mechanism of SGLT1 inhibitors.
Nat Commun, 13, 2022
|
|
7YNJ
 | |
