5YW7

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on SUR1 ABC transporter module at 4.4A)

Summary for 5YW7

Entry DOI	10.2210/pdb5yw7/pdb
EMDB information	6831 6832 6833 6847
Descriptor	ATP-binding cassette sub-family C member 8 isoform X2, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER (3 entities in total)
Functional Keywords	katp, channel, glibenclamide, sulfonylurea, membrane protein
Biological source	Mesocricetus auratus (Golden hamster)
Total number of polymer chains	1
Total formula weight	178312.77
Authors	Chen, L.,Wu, J.X. (deposition date: 2017-11-29, release date: 2018-05-02, Last modification date: 2024-03-27)
Primary citation	Wu, J.X.,Ding, D.,Wang, M.,Kang, Y.,Zeng, X.,Chen, L. Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9:553-567, 2018 Cited by PubMed: 29594720 DOI: 10.1007/s13238-018-0530-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation