7WMV

Structure of human SGLT1-MAP17 complex bound with LX2761

Summary for 7WMV

• Entry DOI: 10.2210/pdb7wmv/pdb
• EMDB information: 32617
• Descriptor: Sodium/glucose cotransporter 1, PDZK1-interacting protein 1, N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide (3 entities in total)
• Functional Keywords: glucose transporter, sglt, sodium glucose transporter, membrane protein, protein transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 86424.59

Authors

Chen, L.,Niu, Y.,Cui, W. (deposition date: 2022-01-17, release date: 2022-11-16)

• Primary citation: Niu, Y.,Cui, W.,Liu, R.,Wang, S.,Ke, H.,Lei, X.,Chen, L.; Structural mechanism of SGLT1 inhibitors.; Nat Commun, 13:6440-6440, 2022; PubMed: 36307403; DOI: 10.1038/s41467-022-33421-7

Experimental method

ELECTRON MICROSCOPY (3.2 Å)