6CJK
| Anti HIV Fab 10A | Descriptor: | ACETATE ION, GLYCEROL, Immunoglobulin Fab heavy chain, ... | Authors: | Hangartner, L, Ward, A.B, Wilson, I.A, Oyen, D. | Deposit date: | 2018-02-26 | Release date: | 2018-08-15 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization. Immunity, 49, 2018
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6CE0
| Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... | Authors: | Kumar, S, Sarkar, A, Wilson, I.A. | Deposit date: | 2018-02-09 | Release date: | 2018-12-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.602 Å) | Cite: | HIV-1 vaccine design through minimizing envelope metastability. Sci Adv, 4, 2018
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7Z3A
| AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACS101 heavy chain, ... | Authors: | van Schooten, J, Ward, A. | Deposit date: | 2022-03-02 | Release date: | 2022-08-10 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein. Nat Commun, 13, 2022
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7ZLK
| AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACS114 heavy chain, ... | Authors: | van Schooten, J, Ozorowski, G, Ward, A. | Deposit date: | 2022-04-15 | Release date: | 2022-09-21 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer. Plos Pathog., 18, 2022
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6DFH
| BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | Authors: | Ozorowski, G, Steichen, J.M, Schief, W.R, Ward, A.B. | Deposit date: | 2018-05-14 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science, 366, 2019
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6DID
| HIV Env BG505 SOSIP with polyclonal Fabs from immunized rabbit #3417 post-boost#1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | Authors: | Turner, H.L, Cottrell, C.A, Oyen, D, Wilson, I.A, Ward, A.B. | Deposit date: | 2018-05-23 | Release date: | 2018-09-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.71 Å) | Cite: | Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization. Immunity, 49, 2018
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6DFG
| BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | Authors: | Ozorowski, G, Steichen, J.M, Schief, W.R, Ward, A.B. | Deposit date: | 2018-05-14 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science, 366, 2019
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7U2E
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADI-55688 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-55688 heavy chain, ADI-55688 light chain, ... | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | Deposit date: | 2022-02-23 | Release date: | 2022-05-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A broad and potent neutralization epitope in SARS-related coronaviruses. Proc.Natl.Acad.Sci.USA, 119, 2022
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6VO1
| BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Cottrell, C.A, Ward, A.B. | Deposit date: | 2020-01-29 | Release date: | 2020-07-01 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
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6VLR
| BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIPv5.2 gp41, ... | Authors: | Cottrell, C.A, Ward, A.B. | Deposit date: | 2020-01-24 | Release date: | 2020-06-24 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
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7U2D
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADG20 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADG20 heavy chain, ADG20 light chain, ... | Authors: | Zhu, X, Yuan, M, Wilson, I.A. | Deposit date: | 2022-02-23 | Release date: | 2022-05-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | A broad and potent neutralization epitope in SARS-related coronaviruses. Proc.Natl.Acad.Sci.USA, 119, 2022
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6VN0
| BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | Authors: | Cottrell, C.A, Shin, M, Ward, A.B. | Deposit date: | 2020-01-29 | Release date: | 2020-06-24 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
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6XC4
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 heavy chain, CC12.3 light chain, ... | Authors: | Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A. | Deposit date: | 2020-06-08 | Release date: | 2020-07-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.341 Å) | Cite: | Structural basis of a shared antibody response to SARS-CoV-2. Science, 369, 2020
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6XC3
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.1 and CR3022 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.1 heavy chain, CC12.1 light chain, ... | Authors: | Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A. | Deposit date: | 2020-06-08 | Release date: | 2020-07-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | Structural basis of a shared antibody response to SARS-CoV-2. Science, 369, 2020
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6XC7
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.3 and CR3022 | Descriptor: | CC12.3 heavy chain, CC12.3 light chain, CR3022 heavy chain, ... | Authors: | Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A. | Deposit date: | 2020-06-08 | Release date: | 2020-07-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.883 Å) | Cite: | Structural basis of a shared antibody response to SARS-CoV-2. Science, 369, 2020
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6XC2
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.1 heavy chain, CC12.1 light chain, ... | Authors: | Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A. | Deposit date: | 2020-06-08 | Release date: | 2020-07-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.112 Å) | Cite: | Structural basis of a shared antibody response to SARS-CoV-2. Science, 369, 2020
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5JSA
| Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kong, L, Wilson, I.A. | Deposit date: | 2016-05-07 | Release date: | 2016-07-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (6.308 Å) | Cite: | Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nat Commun, 7, 2016
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5KZC
| Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Engineered outer domain of gp120, VRC01 Fab heavy chain, ... | Authors: | Julien, J.-P, Jardine, J.G, Diwanji, D, Schief, W.R, Wilson, I.A. | Deposit date: | 2016-07-24 | Release date: | 2016-08-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. Plos Pathog., 12, 2016
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5MP6
| Structure of the Unliganded Fab from HIV-1 Neutralizing Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface, at two Angstrom resolution. | Descriptor: | CAP248-2B Heavy Chain, CAP248-2B Light Chain, SULFATE ION | Authors: | Wibmer, C.K, Gorman, J, Kwong, P.D. | Deposit date: | 2016-12-15 | Release date: | 2016-12-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.959 Å) | Cite: | Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape. PLoS Pathog., 13, 2017
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6I9I
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6MAR
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6MSY
| Anti-HIV-1 Fab Fab 2G12 + Man4 re-refinement | Descriptor: | ACETATE ION, Fab 2G12, light chain, ... | Authors: | Calarese, D.A, Stanfield, R.L, Wilson, I.A. | Deposit date: | 2018-10-18 | Release date: | 2018-11-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proc. Natl. Acad. Sci. U.S.A., 102, 2005
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6MUB
| Anti-HIV-1 Fab 2G12 + Man5 re-refinement | Descriptor: | Fab 2G12, heavy chain, light chain, ... | Authors: | Wilson, I.A, Calarese, D.A, Stanfield, R.L. | Deposit date: | 2018-10-22 | Release date: | 2018-10-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proc.Natl.Acad.Sci.USA, 102, 2005
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6N2X
| Anti-HIV-1 Fab 2G12 + Man9 re-refinement | Descriptor: | Fab 2G12 heavy chain, Fab 2G12 light chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Calarese, D.A, Stanfield, R.L, Wilson, I.A. | Deposit date: | 2018-11-14 | Release date: | 2018-11-28 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science, 300, 2003
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6N35
| Anti-HIV-1 Fab 2G12 + Man1-2 re-refinement | Descriptor: | BENZOIC ACID, Fab 2G12 heavy chain, Fab 2G12 light chain, ... | Authors: | Calarese, D.A, Stanfield, R.L, Wilson, I.A. | Deposit date: | 2018-11-14 | Release date: | 2018-11-28 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.747 Å) | Cite: | Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science, 300, 2003
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