5JSA
Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128
Summary for 5JSA
Entry DOI | 10.2210/pdb5jsa/pdb |
Related | 5JS9 |
Descriptor | broadly neutralizing antibody PGT128 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total) |
Functional Keywords | hiv-1 trimer, ufo, sosip, vaccine, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 180365.45 |
Authors | Kong, L.,Wilson, I.A. (deposition date: 2016-05-07, release date: 2016-07-13, Last modification date: 2023-09-27) |
Primary citation | Kong, L.,He, L.,de Val, N.,Vora, N.,Morris, C.D.,Azadnia, P.,Sok, D.,Zhou, B.,Burton, D.R.,Ward, A.B.,Wilson, I.A.,Zhu, J. Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nat Commun, 7:12040-12040, 2016 Cited by PubMed: 27349805DOI: 10.1038/ncomms12040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (6.308 Å) |
Structure validation
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