5KZC

Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01

Summary for 5KZC

• Entry DOI: 10.2210/pdb5kzc/pdb
• Related: 4JPJ 4JPK 5D9Q
• Descriptor: VRC01 Fab heavy chain, Engineered outer domain of gp120, VRC01 Fab light chain, ... (6 entities in total)
• Functional Keywords: hiv, env, gp120, neutralizing antibody, n-linked glycan, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 9
• Total formula weight: 206912.06

Authors

Julien, J.-P.,Jardine, J.G.,Diwanji, D.,Schief, W.R.,Wilson, I.A. (deposition date: 2016-07-24, release date: 2016-08-10, Last modification date: 2023-10-04)

• Primary citation: Jardine, J.G.,Sok, D.,Julien, J.P.,Briney, B.,Sarkar, A.,Liang, C.H.,Scherer, E.A.,Henry Dunand, C.J.,Adachi, Y.,Diwanji, D.,Hsueh, J.,Jones, M.,Kalyuzhniy, O.,Kubitz, M.,Spencer, S.,Pauthner, M.,Saye-Francisco, K.L.,Sesterhenn, F.,Wilson, P.C.,Galloway, D.M.,Stanfield, R.L.,Wilson, I.A.,Burton, D.R.,Schief, W.R.; Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.; Plos Pathog., 12:e1005815-e1005815, 2016; PubMed: 27560183; DOI: 10.1371/journal.ppat.1005815

Experimental method

X-RAY DIFFRACTION (3.25 Å)