4JPK
Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab
Summary for 4JPK
Entry DOI | 10.2210/pdb4jpk/pdb |
Related | 4JPI 4JPJ |
Descriptor | Putative VRC01 germline precursor Fab heavy chain, Putative VRC01 germline precursor Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ... (5 entities in total) |
Functional Keywords | hiv-1 gp120, cd4 binding, vrc01-like broadly neutralizing antibodies, immune system-viral protein complex, immune system/viral protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 68596.35 |
Authors | Julien, J.-P.,Jardine, J.,Schief, W.R.,Wilson, I.A. (deposition date: 2013-03-19, release date: 2013-04-10, Last modification date: 2023-09-20) |
Primary citation | Jardine, J.,Julien, J.P.,Menis, S.,Ota, T.,Kalyuzhniy, O.,McGuire, A.,Sok, D.,Huang, P.S.,MacPherson, S.,Jones, M.,Nieusma, T.,Mathison, J.,Baker, D.,Ward, A.B.,Burton, D.R.,Stamatatos, L.,Nemazee, D.,Wilson, I.A.,Schief, W.R. Rational HIV immunogen design to target specific germline B cell receptors. Science, 340:711-716, 2013 Cited by PubMed: 23539181DOI: 10.1126/science.1234150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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