5MP6

Structure of the Unliganded Fab from HIV-1 Neutralizing Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface, at two Angstrom resolution.

Summary for 5MP6

• Entry DOI: 10.2210/pdb5mp6/pdb
• Related: 5F89
• Descriptor: CAP248-2B Heavy Chain, CAP248-2B Light Chain, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hiv, neutralizing antibody, gp120 c-terminus, cap248, gp120-gp41 interface, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 99906.55

Authors

Wibmer, C.K.,Gorman, J.,Kwong, P.D. (deposition date: 2016-12-15, release date: 2016-12-28, Last modification date: 2024-01-17)

• Primary citation: Wibmer, C.K.,Gorman, J.,Ozorowski, G.,Bhiman, J.N.,Sheward, D.J.,Elliott, D.H.,Rouelle, J.,Smira, A.,Joyce, M.G.,Ndabambi, N.,Druz, A.,Asokan, M.,Burton, D.R.,Connors, M.,Abdool Karim, S.S.,Mascola, J.R.,Robinson, J.E.,Ward, A.B.,Williamson, C.,Kwong, P.D.,Morris, L.,Moore, P.L.; Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.; PLoS Pathog., 13:e1006074-e1006074, 2017; PubMed: 28076415; DOI: 10.1371/journal.ppat.1006074

Experimental method

X-RAY DIFFRACTION (1.959 Å)