5MP6

Structure of the Unliganded Fab from HIV-1 Neutralizing Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface, at two Angstrom resolution.

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 P 301

Chain	Residue
L	SER27
L	LYS190

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site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 P 302

Chain	Residue
L	GLU204
P	ILE100
P	THR100
P	HOH424

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site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 Q 301

Chain	Residue
Q	ARG42
Q	LYS45
Q	HOH428

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site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 H 301

Chain	Residue
H	ARG38
H	GLU46
H	SER62
H	LEU63
Q	SER166
Q	LYS167
Q	GLN168

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site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 H 302

Chain	Residue
H	ARG105
H	HOH415
L	ARG42
L	ALA43
L	HOH449

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site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 H 303

Chain	Residue
H	THR57
H	HIS58
H	TYR59
H	LYS64
L	HOH404
L	HOH405

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site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 H 304

Chain	Residue
H	GLN3
H	GLN5
H	ARG105
H	HOH410

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 H 305

Chain	Residue
H	VAL27
H	ALA28
H	ASN31
H	HOH416

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site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 H 306

Chain	Residue
H	THR100
Q	VAL156
Q	LYS157
Q	ALA158

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 L 301

Chain	Residue
L	HIS39
L	ARG42
L	LYS45
L	HOH420
L	HOH442

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site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 L 302

Chain	Residue
H	ARG75
L	LYS66
L	ALA68
L	HOH403
L	HOH434

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site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 L 303

Chain	Residue
L	LYS111
L	ASN113
L	SER201
L	HOH409
Q	ARG54
Q	ASP60

---

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 L 304

Chain	Residue
L	SER59
L	ARG61

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site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 L 305

Chain	Residue
L	GLU83
L	THR105
L	TYR141
L	LYS167
L	TYR173
L	HOH408

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site_id	AD6
Number of Residues	8
Details	binding site for Di-peptide PCA H 1 and VAL H 2

Chain	Residue
H	GLN3
H	TYR25
H	GLY26
H	PHE102
H	HOH468
H	HOH482
P	GLN5
P	HOH430

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site_id	AD7
Number of Residues	9
Details	binding site for Di-peptide PCA L 1 and SER L 2

Chain	Residue
H	PRO61
L	ALA3
L	LEU4
L	SER95
L	ALA95
L	VAL97
L	HOH466
L	HOH496
Q	LYS167

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
Q	TYR192-HIS198
P	TYR194-HIS200

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