6O3C
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![BU of 6o3c by Molmil](/molmil-images/mine/6o3c) | Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide, ... | Authors: | Deshpande, I.S, Liang, J, Hedeen, D, Roberts, K.J, Zhang, Y, Ha, B, Latorraca, N.R, Faust, B, Dror, R.O, Beachy, P.A, Myers, B.R, Manglik, A. | Deposit date: | 2019-02-26 | Release date: | 2019-07-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature, 571, 2019
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6MG8
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![BU of 6mg8 by Molmil](/molmil-images/mine/6mg8) | Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched | Descriptor: | CHOLESTEROL, Protein patched homolog 1 | Authors: | Zhang, Y, Bulkley, D, Xin, Y, Roberts, K.J, Asarnow, D.E, Sharma, A, Myers, B.R, Cho, W, Cheng, Y, Beachy, P.A. | Deposit date: | 2018-09-13 | Release date: | 2018-11-28 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell, 175, 2018
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7K65
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![BU of 7k65 by Molmil](/molmil-images/mine/7k65) | Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | Authors: | Zhang, Y, Bulkley, D.P, Liang, J, Manglik, A, Cheng, Y, Beachy, P.A. | Deposit date: | 2020-09-18 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc.Natl.Acad.Sci.USA, 117, 2020
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7RPK
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![BU of 7rpk by Molmil](/molmil-images/mine/7rpk) | Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog | Descriptor: | (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | Deposit date: | 2021-08-03 | Release date: | 2021-10-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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7RPJ
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![BU of 7rpj by Molmil](/molmil-images/mine/7rpj) | Cryo-EM structure of murine Dispatched NNN mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1 | Authors: | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | Deposit date: | 2021-08-03 | Release date: | 2021-10-27 | Last modified: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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7RPH
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![BU of 7rph by Molmil](/molmil-images/mine/7rph) | Cryo-EM structure of murine Dispatched 'R' conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, ... | Authors: | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | Deposit date: | 2021-08-03 | Release date: | 2021-10-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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7RPI
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![BU of 7rpi by Molmil](/molmil-images/mine/7rpi) | Cryo-EM structure of murine Dispatched 'T' conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, ... | Authors: | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | Deposit date: | 2021-08-03 | Release date: | 2021-10-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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1VHH
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![BU of 1vhh by Molmil](/molmil-images/mine/1vhh) | A POTENTIAL CATALYTIC SITE WITHIN THE AMINO-TERMINAL SIGNALLING DOMAIN OF SONIC HEDGEHOG | Descriptor: | SONIC HEDGEHOG, SULFATE ION, ZINC ION | Authors: | Hall, T.M.T, Porter, J.A, Beachy, P.A, Leahy, D.J. | Deposit date: | 1995-10-03 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature, 378, 1995
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1AT0
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![BU of 1at0 by Molmil](/molmil-images/mine/1at0) | 17-kDA fragment of hedgehog C-terminal autoprocessing domain | Descriptor: | 17-HEDGEHOG | Authors: | Hall, T.M.T, Porter, J.A, Young, K.E, Koonin, E.V, Beachy, P.A, Leahy, D.J. | Deposit date: | 1997-08-15 | Release date: | 1997-11-12 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell(Cambridge,Mass.), 91, 1997
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3D1M
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2IC2
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2IBB
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![BU of 2ibb by Molmil](/molmil-images/mine/2ibb) | |
2IBG
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![BU of 2ibg by Molmil](/molmil-images/mine/2ibg) | |
3ODN
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![BU of 3odn by Molmil](/molmil-images/mine/3odn) | |