1CF7
 
 | | STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP | | 分子名称: | DNA (5'-D(*AP*TP*TP*TP*TP*CP*GP*CP*GP*CP*GP*GP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*AP*AP*CP*CP*GP*CP*GP*CP*GP*AP*AP*AP*A)-3'), PROTEIN (TRANSCRIPTION FACTOR DP-2), ... | | 著者 | Zheng, N, Fraenkel, E, Pabo, C.O, Pavletich, N.P. | | 登録日 | 1999-03-24 | | 公開日 | 1999-04-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.
Genes Dev., 13, 1999
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1FBV
 | | STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES | | 分子名称: | SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ... | | 著者 | Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P. | | 登録日 | 2000-07-17 | | 公開日 | 2000-08-30 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
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1LDD
 | | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | | 分子名称: | Anaphase Promoting Complex | | 著者 | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | | 登録日 | 2002-04-08 | | 公開日 | 2002-05-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
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1LDK
 | | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | | 分子名称: | CULLIN HOMOLOG, CYCLIN A/CDK2-ASSOCIATED PROTEIN P19, SKP2-like protein type gamma, ... | | 著者 | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | | 登録日 | 2002-04-08 | | 公開日 | 2002-05-08 | | 最終更新日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
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1LDJ
 | | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | | 分子名称: | Cullin homolog 1, ZINC ION, ring-box protein 1 | | 著者 | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | | 登録日 | 2002-04-08 | | 公開日 | 2002-05-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
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4U8H
 | | Crystal Structure of Mammalian Period-Cryptochrome Complex | | 分子名称: | Cryptochrome-2, Period circadian protein homolog 2, ZINC ION | | 著者 | Nangle, S.N, Rosensweig, C, Koike, N, Tei, H, Takahashi, J.S, Green, C.B, Zheng, N. | | 登録日 | 2014-08-03 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.798 Å) | | 主引用文献 | Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.
Elife, 3, 2014
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6DO4
 | | KLHDC2 ubiquitin ligase in complex with SelS C-end degron | | 分子名称: | Kelch domain-containing protein 2, SELS C-END DEGRON | | 著者 | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | | 登録日 | 2018-06-08 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
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5K1B
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5KMD
 | | Structure of CavAb in complex with amlodipine | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ... | | 著者 | Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A. | | 登録日 | 2016-06-26 | | 公開日 | 2016-08-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
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5KLB
 | | Crystal structure of the CavAb voltage-gated calcium channel(wild-type, 2.7A) | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CALCIUM ION, ... | | 著者 | Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A. | | 登録日 | 2016-06-23 | | 公開日 | 2016-08-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
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5KLS
 | | Structure of CavAb in complex with Br-dihydropyridine derivative UK-59811 | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ... | | 著者 | Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A. | | 登録日 | 2016-06-25 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.299 Å) | | 主引用文献 | Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
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5KMH
 | | Structure of CavAb in complex with Br-verapamil | | 分子名称: | (2~{R})-2-(2-bromophenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ... | | 著者 | Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A. | | 登録日 | 2016-06-27 | | 公開日 | 2016-08-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
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8T6L
 | | Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B | | 分子名称: | (1R)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-9,12-dihydroxy-2,11a-dimethyl-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-7H-9,11b-epoxy-13a,5a-prop[1]enophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl benzoate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ... | | 著者 | Tonggu, L, Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | | 登録日 | 2023-06-16 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.
Nat Commun, 15, 2024
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8DJ1
 | | Crystal structure of NavAb V126T as a basis for the human Nav1.7 Inherited Erythromelalgia S241T mutation | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein | | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | | 登録日 | 2022-06-29 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8DIZ
 | | Crystal structure of NavAb I119T as a basis for the human Nav1.7 Inherited Erythromelalgia I234T mutation | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein | | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | | 登録日 | 2022-06-29 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8DJ0
 | | Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein | | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | | 登録日 | 2022-06-29 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6DSZ
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1MJE
 | | STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX | | 分子名称: | 5'-D(P*TP*TP*TP*TP*TP*T)-3', Deleted in split hand/split foot protein 1, breast cancer 2 | | 著者 | Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P. | | 登録日 | 2002-08-27 | | 公開日 | 2002-09-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
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1MIU
 | | Structure of a BRCA2-DSS1 complex | | 分子名称: | Breast Cancer type 2 susceptibility protein, Deleted in split hand/split foot protein 1, MERCURY (II) ION | | 著者 | Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P. | | 登録日 | 2002-08-23 | | 公開日 | 2002-09-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA
structure
Science, 297, 2002
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6WPG
 | | Structural Basis of Salicylic Acid Perception by Arabidopsis NPR Proteins | | 分子名称: | 2-HYDROXYBENZOIC ACID, Regulatory protein NPR4 | | 著者 | Wang, W, Withers, J, Li, H, Zwack, P.J, Rusnac, D.V, Shi, H, Liu, L, Yan, S, Hinds, T.R, Guttman, M, Dong, X, Zheng, N. | | 登録日 | 2020-04-27 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.283 Å) | | 主引用文献 | Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
Nature, 586, 2020
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7MY4
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4EKW
 | | Crystal structure of the NavAb voltage-gated sodium channel (wild-type, 3.2 A) | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION | | 著者 | Payandeh, J, Gamal El-Din, T.M, Scheuer, T, Zheng, N, Catterall, W.A. | | 登録日 | 2012-04-10 | | 公開日 | 2012-05-16 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | Crystal structure of a voltage-gated sodium channel in two potentially inactivated states.
Nature, 486, 2012
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6O60
 | | Crystal structure of GGTase3-FBXL2-SKP1 complex | | 分子名称: | F-box/LRR-repeat protein 2, Geranylgeranyl transferase type-2 subunit beta, Protein prenyltransferase alpha subunit repeat-containing protein 1, ... | | 著者 | Wang, H, Zheng, N. | | 登録日 | 2019-03-04 | | 公開日 | 2019-06-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
Nat.Struct.Mol.Biol., 26, 2019
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1U6G
 | | Crystal Structure of The Cand1-Cul1-Roc1 Complex | | 分子名称: | Cullin homolog 1, RING-box protein 1, TIP120 protein, ... | | 著者 | Goldenberg, S.J, Shumway, S.D, Cascio, T.C, Garbutt, K.C, Liu, J, Xiong, Y, Zheng, N. | | 登録日 | 2004-07-29 | | 公開日 | 2004-12-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
Cell(Cambridge,Mass.), 119, 2004
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6DO3
 | | KLHDC2 ubiquitin ligase in complex with SelK C-end degron | | 分子名称: | Kelch domain-containing protein 2, SelK C-end Degron | | 著者 | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | | 登録日 | 2018-06-08 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.165 Å) | | 主引用文献 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
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