8DIZ

Crystal structure of NavAb I119T as a basis for the human Nav1.7 Inherited Erythromelalgia I234T mutation

Summary for 8DIZ

Entry DOI	10.2210/pdb8diz/pdb
Descriptor	Ion transport protein, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (2 entities in total)
Functional Keywords	voltage-gated sodium channel ion transport protein, membrane protein
Biological source	Aliarcobacter butzleri RM4018
Total number of polymer chains	1
Total formula weight	33171.94
Authors	Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A. (deposition date: 2022-06-29, release date: 2023-04-12, Last modification date: 2023-10-25)
Primary citation	Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A. Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120:e2219624120-e2219624120, 2023 Cited by PubMed: 36996107 DOI: 10.1073/pnas.2219624120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation