8DJ0
Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation
Summary for 8DJ0
Entry DOI | 10.2210/pdb8dj0/pdb |
Descriptor | Ion transport protein, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (4 entities in total) |
Functional Keywords | voltage-gated sodium channel ion transport protein, membrane protein |
Biological source | Aliarcobacter butzleri RM4018 |
Total number of polymer chains | 1 |
Total formula weight | 34401.70 |
Authors | Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A. (deposition date: 2022-06-29, release date: 2023-04-12, Last modification date: 2023-10-25) |
Primary citation | Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A. Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120:e2219624120-e2219624120, 2023 Cited by PubMed: 36996107DOI: 10.1073/pnas.2219624120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report